Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 오억수 | - |
dc.contributor.author | 장보희 | - |
dc.date.accessioned | 2020-02-07T16:30:11Z | - |
dc.date.available | 2020-02-07T16:30:11Z | - |
dc.date.issued | 2020 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.other | OAK-26414 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/253330 | - |
dc.description.abstract | D-tyrosine is known to negatively regulate melanin synthesis by inhibiting tyrosinase activity. Here, we further reveal that peptides containing terminal D-tyrosine can reduce the melanin contents of human melanocytes. The addition of D-tyrosine to the terminus of the commercial anti-wrinkle peptide, pentapeptide-18 endowed the peptide with the ability to reduce the melanin content and tyrosinase activity in human MNT-1 melanoma cells and primary melanocytes. Consistently, terminal D-tyrosine-containing pentapeptide-18 inhibited the melanogenesis induced by a-MSH treatment or UV irradiation of MNT-1 cells and reduced melanin synthesis in the epidermal basal layer of a 3D human skin model. Furthermore, the addition of D-tyrosine to an anti-aging peptide (GEKG) or an anti-inflammatory peptide (GHK) endowed these short peptides with anti-melanogenic effects without altering their intrinsic effects. Together, these data suggest that the addition of D-tyrosine at the terminus of a short cosmetic peptide adds an anti-melanogenic effect to its intrinsic cosmetic effect. Our work offers a novel means of generating dual-function cosmetic peptides. | - |
dc.language | English | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | D-tyrosine adds an anti-melanogenic effect to cosmetic peptides | - |
dc.type | Article | - |
dc.relation.issue | 1 | - |
dc.relation.volume | 10 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.journaltitle | SCIENTIFIC REPORTS | - |
dc.identifier.doi | 10.1038/s41598-019-57159-3 | - |
dc.identifier.wosid | WOS:000551362100002 | - |
dc.identifier.scopusid | 2-s2.0-85077856404 | - |
dc.author.google | Park, Jisu | - |
dc.author.google | Jung, Hyejung | - |
dc.author.google | Jang, Bohee | - |
dc.author.google | Song, Hyun-Kuk | - |
dc.author.google | Han, Inn-Oc | - |
dc.author.google | Oh, Eok-Soo | - |
dc.contributor.scopusid | 오억수(7101967153) | - |
dc.contributor.scopusid | 장보희(55242403100) | - |
dc.date.modifydate | 20230201093717 | - |