Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 심경원 | - |
dc.date.accessioned | 2020-02-07T16:30:08Z | - |
dc.date.available | 2020-02-07T16:30:08Z | - |
dc.date.issued | 2020 | - |
dc.identifier.issn | 2072-6643 | - |
dc.identifier.other | OAK-26425 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/253320 | - |
dc.description.abstract | Probiotics can improve the intestinal environment by enhancing beneficial bacteria to potentially regulate lipid levels; however, the underlying mechanisms remain unclear. The aim of this study was to investigate the effect of Lactobacillus plantarum Q180 (LPQ180) on postprandial lipid metabolism and the intestinal microbiome environment from a clinical perspective. A double-blind, randomized, placebo-controlled study was conducted including 70 participants of both sexes, 20 years of age and older, with healthy blood triacylglyceride (TG) levels below 200 mg/dL. Treatment with LPQ180 for 12 weeks significantly decreased LDL-cholesterol (p = 0.042) and apolipoprotein (Apo)B-100 (p = 0.003) levels, and decreased postprandial maximum concentrations (C-max) and areas under the curve (AUC) of TG, chylomicron TG, ApoB-48, and ApoB-100. LPQ180 treatment significantly decreased total indole and phenol levels (p = 0.019). In addition, there was a negative correlation between baseline microbiota abundance and lipid marker change, which was negatively correlated with metabolites. This study suggests that LPQ180 might be developed as a functional ingredient to help maintain healthy postprandial lipid levels through modulating gut environment. | - |
dc.language | English | - |
dc.publisher | MDPI | - |
dc.subject | postprandial lipids | - |
dc.subject | intestinal microbiota | - |
dc.subject | intestinal microbiota metabolites | - |
dc.subject | correlation | - |
dc.subject | lipid mechanism | - |
dc.subject | LPQ180 | - |
dc.subject | probiotics | - |
dc.title | Effects of Lactobacillus plantarum Q180 on Postprandial Lipid Levels and Intestinal Environment: A Double-Blind, Randomized, Placebo-Controlled, Parallel Trial | - |
dc.type | Article | - |
dc.relation.issue | 1 | - |
dc.relation.volume | 12 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.journaltitle | NUTRIENTS | - |
dc.identifier.doi | 10.3390/nu12010255 | - |
dc.identifier.wosid | WOS:000516825500255 | - |
dc.identifier.scopusid | 2-s2.0-85078102284 | - |
dc.author.google | Park, Ye Eun | - |
dc.author.google | Kim, Min Seo | - |
dc.author.google | Shim, Kyung Won | - |
dc.author.google | Kim, You-Il | - |
dc.author.google | Chu, Jaeryang | - |
dc.author.google | Kim, Byoung-Kook | - |
dc.author.google | Choi, In Suk | - |
dc.author.google | Kim, Ji Yeon | - |
dc.contributor.scopusid | 심경원(8724567500) | - |
dc.date.modifydate | 20200413113227 | - |