Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 문병인 | * |
dc.contributor.author | 임우성 | * |
dc.contributor.author | 권형주 | * |
dc.contributor.author | 우주현 | * |
dc.date.accessioned | 2020-01-14T16:30:09Z | - |
dc.date.available | 2020-01-14T16:30:09Z | - |
dc.date.issued | 2020 | * |
dc.identifier.issn | 0258-851X | * |
dc.identifier.issn | 1791-7549 | * |
dc.identifier.other | OAK-26263 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/252376 | - |
dc.description.abstract | Background/Aim: MEK-ERK pathway plays major roles in the progression of thyroid cancer, while the use of MEK-ERK inhibitors has been limited by its toxicity. We investigated the effect of sodium selenite as an adjunct for MEK-ERK inhibitors to avoid the toxicity of ERK inhibitors. Materials and Methods: TPC1, 8505C and HTori-3 cells were treated with U0126 (MEK-ERK inhibitor) and cell viability was counted in the Neubauer chamber. The synergistic effects of sodium selenite and U0126 were also measured. The expression of ERK, p-ERK, and p90(RSK) was determined by western blot. Results: Treatment with U0126 inhibited proliferation of TPC1 and 8505C cells in a dose-dependent manner. When 5 mu M sodium selenite was added to 1 mu M U0126, relative cell survival further decreased. Decreased expression of p90(RSK) indicated that sodium selenite down-regulated ERK signaling in thyroid cancer cells. Conclusion: The combination of U0126 and sodium selenite inhibited proliferation of thyroid cancer cells through ERK inhibition. | * |
dc.language | English | * |
dc.publisher | INT INST ANTICANCER RESEARCH | * |
dc.subject | Selenium | * |
dc.subject | thyroid cancer | * |
dc.subject | MEK-ERK inhibitor | * |
dc.subject | U0126 | * |
dc.subject | ERK pathway | * |
dc.title | Sodium Selenite Enhanced the Anti-proliferative Effect of MEK-ERK Inhibitor in Thyroid Cancer Cells | * |
dc.type | Article | * |
dc.relation.issue | 1 | * |
dc.relation.volume | 34 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 185 | * |
dc.relation.lastpage | 190 | * |
dc.relation.journaltitle | IN VIVO | * |
dc.identifier.doi | 10.21873/invivo.11760 | * |
dc.identifier.wosid | WOS:000504753200022 | * |
dc.identifier.scopusid | 2-s2.0-85077242812 | * |
dc.author.google | Kim, Jong Bin | * |
dc.author.google | Yang, Eun Yeol | * |
dc.author.google | Woo, Joohyun | * |
dc.author.google | Kwon, Hyungju | * |
dc.author.google | Lim, Woosung | * |
dc.author.google | Moon, Byung-In | * |
dc.contributor.scopusid | 문병인(7101878644;56119062300) | * |
dc.contributor.scopusid | 임우성(27167744500) | * |
dc.contributor.scopusid | 권형주(57189926616) | * |
dc.contributor.scopusid | 우주현(56211277800) | * |
dc.date.modifydate | 20240318132538 | * |