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Sodium Selenite Enhanced the Anti-proliferative Effect of MEK-ERK Inhibitor in Thyroid Cancer Cells
- Title
- Sodium Selenite Enhanced the Anti-proliferative Effect of MEK-ERK Inhibitor in Thyroid Cancer Cells
- Authors
- Kim, Jong Bin; Yang, Eun Yeol; Woo, Joohyun; Kwon, Hyungju; Lim, Woosung; Moon, Byung-In
- Ewha Authors
- 문병인; 임우성; 권형주; 우주현
- SCOPUS Author ID
- 문병인; 임우성; 권형주; 우주현
- Issue Date
- 2020
- Journal Title
- IN VIVO
- ISSN
- 0258-851X
1791-7549
- Citation
- IN VIVO vol. 34, no. 1, pp. 185 - 190
- Keywords
- Selenium; thyroid cancer; MEK-ERK inhibitor; U0126; ERK pathway
- Publisher
- INT INST ANTICANCER RESEARCH
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Background/Aim: MEK-ERK pathway plays major roles in the progression of thyroid cancer, while the use of MEK-ERK inhibitors has been limited by its toxicity. We investigated the effect of sodium selenite as an adjunct for MEK-ERK inhibitors to avoid the toxicity of ERK inhibitors. Materials and Methods: TPC1, 8505C and HTori-3 cells were treated with U0126 (MEK-ERK inhibitor) and cell viability was counted in the Neubauer chamber. The synergistic effects of sodium selenite and U0126 were also measured. The expression of ERK, p-ERK, and p90(RSK) was determined by western blot. Results: Treatment with U0126 inhibited proliferation of TPC1 and 8505C cells in a dose-dependent manner. When 5 mu M sodium selenite was added to 1 mu M U0126, relative cell survival further decreased. Decreased expression of p90(RSK) indicated that sodium selenite down-regulated ERK signaling in thyroid cancer cells. Conclusion: The combination of U0126 and sodium selenite inhibited proliferation of thyroid cancer cells through ERK inhibition.
- DOI
- 10.21873/invivo.11760
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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