Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이종란 | - |
dc.contributor.author | 윤영대 | - |
dc.date.accessioned | 2019-12-03T16:30:38Z | - |
dc.date.available | 2019-12-03T16:30:38Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 0818-9641 | - |
dc.identifier.issn | 1440-1711 | - |
dc.identifier.other | OAK-26124 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/252347 | - |
dc.description.abstract | Previously, we reported induced expression of the p190 Rho guanine nucleotide exchange factor (p190RhoGEF, ARHGEF28) following CD40 stimulation of B cells isolated from mouse spleen. We also reported that p190RhoGEF and a downstream effector molecule RhoA are required for B-cell differentiation, especially for the induction of the plasma cell (PC) differentiation. This study investigates the role of p190RhoGEF in B-cell biology in vivo, using p190RhoGEF transgenic (TG) mice that overexpress a wild-type full gene in B cells. Immunization of these mice with T-cell-dependent antigen showed that populations of germinal center B cells and PCs were significantly increased in TG mice. Furthermore, similar results were shown in recombination activating 1 (Rag1) knockout mice that were reconstituted with B cells isolated from TG mice in combination with T cells isolated from littermate control mice. Analyses of isotype class switching and transcription factors involved in a germinal center reaction and PC differentiation also supported the findings from the cellular responses. These results suggest that p190RhoGEF may play a role in the stage of PC differentiation during T-cell-dependent humoral immune responses. | - |
dc.language | English | - |
dc.publisher | WILEY | - |
dc.subject | B cells | - |
dc.subject | CD40 signaling | - |
dc.subject | humoral immune responses | - |
dc.subject | p190RhoGEF | - |
dc.subject | plasma cells | - |
dc.title | Over-expression of p190RhoGEF enhances B-cell activation and germinal center formation in T-cell-dependent humoral immune responses | - |
dc.type | Article | - |
dc.relation.issue | 10 | - |
dc.relation.volume | 97 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 877 | - |
dc.relation.lastpage | 887 | - |
dc.relation.journaltitle | IMMUNOLOGY AND CELL BIOLOGY | - |
dc.identifier.doi | 10.1111/imcb.12286 | - |
dc.identifier.wosid | WOS:000483894900001 | - |
dc.identifier.scopusid | 2-s2.0-85071287427 | - |
dc.author.google | Jeong, Ji Hye | - |
dc.author.google | Ha, Yun Jung | - |
dc.author.google | Choi, So-Yeon | - |
dc.author.google | Kim, Jee-Hae | - |
dc.author.google | Yun, Yungdae | - |
dc.author.google | Lee, Jong Ran | - |
dc.contributor.scopusid | 이종란(37960967100) | - |
dc.contributor.scopusid | 윤영대(7201731033) | - |
dc.date.modifydate | 20230411105011 | - |