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dc.contributor.author서은경-
dc.contributor.author우현애-
dc.date.accessioned2019-12-03T16:30:35Z-
dc.date.available2019-12-03T16:30:35Z-
dc.date.issued2019-
dc.identifier.issn0367-326X-
dc.identifier.issn1873-6971-
dc.identifier.otherOAK-26140-
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/252332-
dc.description.abstractBioassay-guided fractionation of an extract of leaves and twigs of Elaeagnus umbellata led to the isolation of a serotonin derivative, N-[2-(5-hydroxyl-1H-indol-3-yl)ethyl]-butanamide (1), along with six flavonoid glycosides, kaempferol-3-O-beta-D-xylopyranosyl(1 -> 2)-beta-D-galactopyranoside-7-O-alpha-L-rhamnopyranoside (2), kaempferol-3-O-beta-D-galactopyranoside-7-O-alpha-L-rhamnopyranoside (3), kaempferol-3-O-alpha-L-rhamnopyranosyl(1 -> 6)-beta-D-galactopyranoside-7-O-alpha-L-rhamnopyranoside (4), kaempferol-3-O-beta-D-xylopyranosyl(1 -> 2)-beta-D-galactopyranoside (5), kaempferol-3-O-rutinoside (6), and kaempferol-3-O-beta-D-glucopyranosyl(1 -> 2)-beta-D-galactopyranoside-7-O-alpha-L-rhamnopyranoside (7). Their structures were elucidated using 1D/2D nuclear magnetic resonance spectroscopy and mass spectrometry. Compounds 1-6 were evaluated for their proliferative effects on HaCaT keratinocytes; 1-5 promoted keratinocyte proliferation dose dependently. Compounds 3 and 4 showed potent activities. These results suggest that the leaves and twigs of E. umbellata have wound healing and skin cell regeneration potentials.-
dc.languageEnglish-
dc.publisherELSEVIER-
dc.subjectElaeagnus umbellata-
dc.subjectElaeagnaceae-
dc.subjectSerotonin derivative-
dc.subjectFlavonoid glycoside-
dc.subjectCell proliferation-
dc.subjectHaCaT keratinocyte-
dc.titleConstituents of the leaves and twigs of Elaeagnus umbellata and their proliferative effects on human keratinocyte HaCaT cells-
dc.typeArticle-
dc.relation.volume139-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.journaltitleFITOTERAPIA-
dc.identifier.doi10.1016/j.fitote.2019.104374-
dc.identifier.wosidWOS:000501622300023-
dc.identifier.scopusid2-s2.0-85074341997-
dc.author.googlePaudel, Sunil Babu-
dc.author.googlePark, Jiyoung-
dc.author.googleKim, Nam Hee-
dc.author.googleChoi, Hyukjae-
dc.author.googleSeo, Eun-Kyoung-
dc.author.googleWoo, Hyun Ae-
dc.author.googleNam, Joo-Won-
dc.contributor.scopusid서은경(7005953758)-
dc.contributor.scopusid우현애(8068619500)-
dc.date.modifydate20211117115846-
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약학대학 > 약학과 > Journal papers
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