View : 289 Download: 0

Circulating tumor cells are associated with poor outcomes in early-stage hepatocellular carcinoma: a prospective study

Title
Circulating tumor cells are associated with poor outcomes in early-stage hepatocellular carcinoma: a prospective study
Authors
Ha, YeonjungKim, Tae HunShim, Jae EulYoon, SunghyunJun, Mi JungCho, Young-HoLee, Han Chu
Ewha Authors
김태헌
SCOPUS Author ID
김태헌scopus
Issue Date
2019
Journal Title
HEPATOLOGY INTERNATIONAL
ISSN
1936-0533JCR Link

1936-0541JCR Link
Citation
HEPATOLOGY INTERNATIONAL vol. 13, no. 6, pp. 726 - 735
Keywords
Circulating tumor cellsNanomedicineHepatocellular carcinomaRecurrenceSurvival
Publisher
SPRINGER
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
BackgroundPrevious studies evaluating association between circulating tumor cells (CTCs) and clinical outcomes in hepatocellular carcinoma (HCC) have shown inconsistent results due to suboptimal detection methods and patient heterogeneity.MethodsPatients undergoing surgery for early-stage HCC were prospectively enrolled. The CTC numbers were determined using a tapered slit platform, which detects CTCs based on the cell size and morphology. Survival and recurrence were evaluated, and Cox proportional hazards models were used to demonstrate the prognostic significance of CTC.ResultsOf 105 patients, 25 had increased CTC numbers after surgery (Delta CTC>0, defined as positive) and a significantly higher level of recurrence (p=0.042). A positive Delta CTC was seen to be an independent predictor of recurrence (hazard ratio 2.28), along with hepatitis B virus infection, alanine aminotransferase level, and the presence of satellite nodules (all p<0.05). Subgroup analyses showed that a positive Delta CTC was associated with lower survival and higher recurrence among patients with low alpha-fetoprotein levels and cirrhosis (all p<0.05).ConclusionCalculation of Delta CTC based on the physical properties of the cells is predictive of recurrence in patients with early HCC undergoing surgery.
Show the fulltext
DOI
10.1007/s12072-019-09994-9
Appears in Collections:
의과대학 > 의학과 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE