Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 윤여준 | - |
dc.date.accessioned | 2019-12-03T16:30:14Z | - |
dc.date.available | 2019-12-03T16:30:14Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 1367-5435 | - |
dc.identifier.issn | 1476-5535 | - |
dc.identifier.other | OAK-26081 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/252263 | - |
dc.description.abstract | Methylated flavonoids possess improved bioactivities compared to their unmethylated counterparts. In this study, for the efficient production of O-methylated flavonoids from simple methylated phenylpropanoic acids, a recombinant Escherichia coli strain expressing 4-coumarate:coenzyme A ligase (4CL) from Oryza sativa and chalcone synthase (CHS) from Hordeum vulgare was constructed; this strain produced significant amount of homoeriodictyol (similar to 52 mg/L) as well as a few amount of hesperetin (0.4 mg/L), respectively, from ferulic acid and 4-methylcaffeic acid. This demonstrates, for the first time, that the scarce but valuable methylated flavanones can be successfully produced from methylated phenylpropanoic acids in a microbial host via an artificial biosynthetic pathway consisting of 4CL and CHS that can accept O-methylated precursors. | - |
dc.language | English | - |
dc.publisher | SPRINGER HEIDELBERG | - |
dc.subject | Methylated flavanone | - |
dc.subject | Microbial production | - |
dc.subject | Homoeriodictyol | - |
dc.subject | Phenylpropanoic acid | - |
dc.subject | Escherichia coli | - |
dc.title | Microbial production of O-methylated flavanones from methylated phenylpropanoic acids in engineered Escherichia coli | - |
dc.type | Article | - |
dc.relation.issue | 12 | - |
dc.relation.volume | 46 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 1707 | - |
dc.relation.lastpage | 1713 | - |
dc.relation.journaltitle | JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY | - |
dc.identifier.doi | 10.1007/s10295-019-02239-6 | - |
dc.identifier.wosid | WOS:000496313400007 | - |
dc.identifier.scopusid | 2-s2.0-85074539243 | - |
dc.author.google | Cui, Heqing | - |
dc.author.google | Song, Myoung Chong | - |
dc.author.google | Lee, Ji Young | - |
dc.author.google | Yoon, Yeo Joon | - |
dc.contributor.scopusid | 윤여준(7402126465) | - |
dc.date.modifydate | 20210708161345 | - |