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dc.contributor.author윤여준-
dc.date.accessioned2019-12-03T16:30:14Z-
dc.date.available2019-12-03T16:30:14Z-
dc.date.issued2019-
dc.identifier.issn1367-5435-
dc.identifier.issn1476-5535-
dc.identifier.otherOAK-26081-
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/252263-
dc.description.abstractMethylated flavonoids possess improved bioactivities compared to their unmethylated counterparts. In this study, for the efficient production of O-methylated flavonoids from simple methylated phenylpropanoic acids, a recombinant Escherichia coli strain expressing 4-coumarate:coenzyme A ligase (4CL) from Oryza sativa and chalcone synthase (CHS) from Hordeum vulgare was constructed; this strain produced significant amount of homoeriodictyol (similar to 52 mg/L) as well as a few amount of hesperetin (0.4 mg/L), respectively, from ferulic acid and 4-methylcaffeic acid. This demonstrates, for the first time, that the scarce but valuable methylated flavanones can be successfully produced from methylated phenylpropanoic acids in a microbial host via an artificial biosynthetic pathway consisting of 4CL and CHS that can accept O-methylated precursors.-
dc.languageEnglish-
dc.publisherSPRINGER HEIDELBERG-
dc.subjectMethylated flavanone-
dc.subjectMicrobial production-
dc.subjectHomoeriodictyol-
dc.subjectPhenylpropanoic acid-
dc.subjectEscherichia coli-
dc.titleMicrobial production of O-methylated flavanones from methylated phenylpropanoic acids in engineered Escherichia coli-
dc.typeArticle-
dc.relation.issue12-
dc.relation.volume46-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage1707-
dc.relation.lastpage1713-
dc.relation.journaltitleJOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY-
dc.identifier.doi10.1007/s10295-019-02239-6-
dc.identifier.wosidWOS:000496313400007-
dc.identifier.scopusid2-s2.0-85074539243-
dc.author.googleCui, Heqing-
dc.author.googleSong, Myoung Chong-
dc.author.googleLee, Ji Young-
dc.author.googleYoon, Yeo Joon-
dc.contributor.scopusid윤여준(7402126465)-
dc.date.modifydate20210708161345-
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자연과학대학 > 화학·나노과학전공 > Journal papers
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