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Histologically proven non- alcoholic fatty liver disease and clinically related factors in recipients after liver transplantation
- Title
- Histologically proven non- alcoholic fatty liver disease and clinically related factors in recipients after liver transplantation
- Authors
- Kim, Hyeyoung; Lee, Kyoungbun; Lee, Kwang-Woong; Yi, Nam-Joon; Lee, Hae Won; Hong, Geun; Choi, YoungRok; You, Tae; Suh, Suk-Won; Jang, Ja June; Suh, Kyung-Suk
- Ewha Authors
- 홍근
- SCOPUS Author ID
- 홍근
- Issue Date
- 2014
- Journal Title
- CLINICAL TRANSPLANTATION
- ISSN
- 0902-0063
1399-0012
- Citation
- CLINICAL TRANSPLANTATION vol. 28, no. 5, pp. 521 - 529
- Keywords
- biopsy; hepatic steatosis; histology; steatohepatitis; steatosis; transplant
- Publisher
- WILEY
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Non-alcoholic fatty liver disease (NAFLD) affects a substantial proportion of the world population, and its prevalence has been increasing. The study was aimed at evaluating the prevalence and peri-transplant risk factors for post-liver transplantation (LT) NAFLD. A retrospective review was performed for adult recipients who underwent late protocol biopsy (>1yr after LT) between August 2010 and December 2012. Hepatic steatosis was reviewed and graded by hepatopathologists, and the peri-transplant factors were analyzed for relationships to histologically proven NAFLD. Total 166 biopsies had been performed in 156 recipients. NAFLD was present in 27.1% at a mean period of 35.4months between LT and biopsy, moderate and severe steatosis (33%) consisted of 28.9%. In multivariate analysis, pre-LT alcoholic cirrhosis (odds ratio [OR] 8.031, p=0.003), obesity at biopsy (OR 3.873, p=0.001), and preexisting donor graft steatosis (OR 3.147, p=0.022) were significant risk factors for post-LT NAFLD. In conclusion, NAFLD represented a considerable portion of recipients, but this prevalence was not higher than those for general population. Three risk factors were significantly related to post-LT NAFLD, and recipients with those factors should be monitored for NAFLD. Furthermore, possible progression to non-alcoholic steatohepatitis (NASH) or fibrosis and metabolic syndrome should be considered in future studies.
- DOI
- 10.1111/ctr.12343
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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