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Usefulness of Preoperative C-Reactive Protein and Alpha-Fetoprotein Levels for Prognostication of Patients with Hepatocellular Carcinoma after Living Donor Liver Transplantation

Title
Usefulness of Preoperative C-Reactive Protein and Alpha-Fetoprotein Levels for Prognostication of Patients with Hepatocellular Carcinoma after Living Donor Liver Transplantation
Authors
Mori, ShozoChoi, YoungrokPark, Min-SuKim, HyeyoungHong, GeunYi, Nam-JoonLee, Kwang-WoongSuh, Kyung-Suk
Ewha Authors
홍근
SCOPUS Author ID
홍근scopus
Issue Date
2014
Journal Title
HEPATO-GASTROENTEROLOGY
ISSN
0172-6390JCR Link
Citation
HEPATO-GASTROENTEROLOGY vol. 61, no. 136, pp. 2353 - 2358
Keywords
Milan criteriaLiver transplantationInflammationC-reactive proteinAlpha-fetoproteinHepatocellular carcinoma
Publisher
H G E UPDATE MEDICAL PUBLISHING S A
Indexed
SCOPUS WOS
Document Type
Article
Abstract
Background/Aims: The C-reactive protein level has been reported as a prognostic predictor for hepatocellular carcinoma after surgery We investigated the usefulness of preoperative C-reactive protein levels in predicting outcomes after living donor liver transplantation for hepatocellular carcinoma and identified preoperative risk factors. Methodology: We retrospectively analyzed 96 hepatocellular carcinoma patients who underwent living donor liver transplantation in March 2003-November 2009. The effect of preoperative variables on overall survival was evaluated by multivariate analysis. Results: The 5-year overall survival rate was significantly lower for C-reactive protein levels >0.3mg/dL than for C-reactive protein levels <= 0.3mg/dL (55.8% vs. 89.8%; P=0.001). In multivariate analysis, C-reactive protein levels >0.3mg/dL (P=0.006) and alpha-fetoprotein levels >200ng/mL (P<0.001) were significant risk factors for survival. For patients within Milan criteria (n=68), the 3-year overall survival rate with 2 risk factors (n=8) was 20%; of these patients, 63% experienced recurrence. For patients outside Milan criteria (n=28), the 5-year overall survival rate without 1-2 risk factors (n=21) was 80.9%; of these patients, 33% experienced recurrence. Conclusions: Preoperative C-reactive protein levels predicted prognosis after living donor liver transplantation for hepatocellular carcinoma. C-reactive protein and alpha-fetoprotein levels together with Milan criteria may improve hepatocellular carcinoma patient selection for liver transplantation.
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DOI
10.5754/hge13322
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의과대학 > 의학과 > Journal papers
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