Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 김규보 | * |
dc.date.accessioned | 2019-11-19T16:31:00Z | - |
dc.date.available | 2019-11-19T16:31:00Z | - |
dc.date.issued | 2015 | * |
dc.identifier.issn | 0167-8140 | * |
dc.identifier.other | OAK-25807 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/252061 | - |
dc.description.abstract | Background and purpose: The Korean Radiation Oncology Group evaluated the significance of carcinoembryonic antigen (CEA) levels both as a predictor of tumor response after CRT and, as a prognosticator for recurrence-free survival. Methods and materials: 1804 rectal cancer patients,.staged cT3-4N0-2M0, participated in a multicenter study. The patients were administered preoperative radiation of 50.4 Gy in 28 fractions with 5-FU or capecitabine, followed by total mesorectal excision. Patients with elevated CEA levels (>5 ng/mL) were matched at a 1 (n = 595):1 (n = 595) ratio with patients with normal CEA ng/mL). The tumor response after CRT and the recurrence-free survival (RFS) rates were evaluated and compared between two arms. Results: An elevated CEA level (p < 0.001) was determined to be a significant negative predictor of downstaging after CRT. The downstaging rate was 42.9% for normal CEA and 23.4% for elevated CEA. A multivariate analysis also revealed that cT (p = 0.021) and cN classification (p = 0.001), tumor size (p = 0.002), and tumor location from the anal verge (p = 0.006) were significant predictors for tumor downstaging. The 5-year RFS rates were significantly higher for the normal CEA arm than for the elevated CEA arm (74.2 vs. 63.5%, p < 0.001). Conclusions: Elevated CEA (>5 ng/mL) is a negative predictor of tumor downstaging after CRT and also has a negative impact on RFS in rectal cancer. (C) 2015 Elsevier Ireland Ltd. All rights reserved. | * |
dc.language | English | * |
dc.publisher | ELSEVIER IRELAND LTD | * |
dc.subject | CEA | * |
dc.subject | Chemoradiotherapy | * |
dc.subject | Rectal cancer | * |
dc.subject | Response | * |
dc.subject | Recurrence | * |
dc.title | Carcinoembryonic antigen has prognostic value for tumor downstaging and recurrence in rectal cancer after preoperative chemoradiotherapy and curative surgery: A multi-institutional and case-matched control study of KROG 14-12 | * |
dc.type | Article | * |
dc.relation.issue | 2 | * |
dc.relation.volume | 116 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 202 | * |
dc.relation.lastpage | 208 | * |
dc.relation.journaltitle | RADIOTHERAPY AND ONCOLOGY | * |
dc.identifier.doi | 10.1016/j.radonc.2015.07.049 | * |
dc.identifier.wosid | WOS:000363077700008 | * |
dc.author.google | Lee, Jong Hoon | * |
dc.author.google | Kim, Nae Yong | * |
dc.author.google | Kim, Sung Hwan | * |
dc.author.google | Cho, Hyeon Min | * |
dc.author.google | Shim, Byoung Yong | * |
dc.author.google | Kim, Tae Hyun | * |
dc.author.google | Kim, Sun Young | * |
dc.author.google | Baek, Ji Yeon | * |
dc.author.google | Oh, Jae Hwan | * |
dc.author.google | Nam, Taek Keun | * |
dc.author.google | Yoon, Mee Sun | * |
dc.author.google | Jeong, Jae Uk | * |
dc.author.google | Kim, Kyubo | * |
dc.author.google | Chie, Eui Kyu | * |
dc.author.google | Jang, Hong Seok | * |
dc.author.google | Kim, Jae-Sung | * |
dc.author.google | Kim, Jin Hee | * |
dc.author.google | Jeong, Bae Kwon | * |
dc.contributor.scopusid | 김규보(8213302900) | * |
dc.date.modifydate | 20240222162403 | * |