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High ratio of programmed cell death protein 1 (PD-1)(+)/CD8(+) tumor-infiltrating lymphocytes identifies a poor prognostic subset of extrahepatic bile duct cancer undergoing surgery plus adjuvant chemoradiotherapy
- Title
- High ratio of programmed cell death protein 1 (PD-1)(+)/CD8(+) tumor-infiltrating lymphocytes identifies a poor prognostic subset of extrahepatic bile duct cancer undergoing surgery plus adjuvant chemoradiotherapy
- Authors
- Lim, Yu Jin; Koh, Jaemoon; Kim, Kyubo; Chie, Eui Kyu; Kim, BoKyong; Lee, Kyoung Bun; Jang, Jin-Young; Kim, Sun-Whe; Oh, Do-Youn; Bang, Yung-Jue; Ha, Sung W.
- Ewha Authors
- 김규보
- SCOPUS Author ID
- 김규보
- Issue Date
- 2015
- Journal Title
- RADIOTHERAPY AND ONCOLOGY
- ISSN
- 0167-8140
1879-0887
- Citation
- RADIOTHERAPY AND ONCOLOGY vol. 117, no. 1, pp. 165 - 170
- Keywords
- Programmed cell death 1 protein; Programmed cell death 1 ligand 1 protein; CD8; Bile duct neoplasms; Adjuvant chemoradiotherapy
- Publisher
- ELSEVIER IRELAND LTD
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Background and purpose: This study investigated the prognostic role of PD-L1 expression, PD-1(+) tumor-infiltrating lymphocytes (TILs), and the ratio of PD-1(+)/CD8(+) TILs in extrahepatic bile duct (EHBD) cancer. Materials and methods: We analyzed 83 patients with EHBD cancer who underwent curative surgery plus fluoropyrimidine-based chemoradiotherapy (CRT). Expressions of PD-L1, PD-1, and CD8 were assessed by immunohistochemistry. Results: Fifty-six (68%) patients were PD-L1-positive, and its lower expression level was associated with hilar tumor location (P = 0.044). A higher ratio of PD-1(+)/CD8(+) TILs was associated with poorer overall survival (OS) (P = 0.032), relapse-free survival (RFS) (P = 0.024), and distant metastasis-free survival (DMFS) (P = 0.039) in Kaplan-Meier analyses, but survival differences were not observed according to the PD-L1 expression level. With Cox proportional hazards models, the ratio of PD-1(+)/CD8(+) TILs was the independent prognostic factor in OS (HR 2.47, 95% CI 1.04-5.86), RFS (HR 2.41, 95% CI 1.08-5.41), and DMFS (HR 2.67, 95% CI 1.00-7.11) after adjusting for other significant clinicopathologic variables. Conclusion: A strong survival impact of the ratio of PD-1(+)/CD8(+) TILs was observed in EHBD cancer. In the poor prognostic subgroup, the blockade of the immune checkpoint in combination with conventional multimodality treatment needs to be considered. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
- DOI
- 10.1016/j.radonc.2015.07.003
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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