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Role of Adjuvant Radiotherapy in Left-Sided Pancreatic Cancer-Population-Based Analysis with Propensity Score Matching

Title
Role of Adjuvant Radiotherapy in Left-Sided Pancreatic Cancer-Population-Based Analysis with Propensity Score Matching
Authors
Lim, Yu JinKim, KyuboChie, Eui KyuKim, BoKyongHa, Sung W.
Ewha Authors
김규보
SCOPUS Author ID
김규보scopus
Issue Date
2015
Journal Title
JOURNAL OF GASTROINTESTINAL SURGERY
ISSN
1091-255XJCR Link

1873-4626JCR Link
Citation
JOURNAL OF GASTROINTESTINAL SURGERY vol. 19, no. 12, pp. 2183 - 2191
Keywords
Adjuvant radiotherapyPancreatic cancerLeft-sided pancreasSEERSurvival
Publisher
SPRINGER
Indexed
SCIE; SCOPUS WOS
Document Type
Article

Proceedings Paper
Abstract
This population-based study evaluated the survival impact of postoperative radiotherapy (PORT) in left-sided pancreatic cancer. The Surveillance, Epidemiology, and End Results (SEER) database was used to identify patients with surgically resected left-sided pancreatic adenocarcinoma from 2004 to 2010. Propensity score matching was conducted to compare PORT and non-PORT groups. A total of 445 patients were identified, and PORT was performed in 180 (40 %) patients. In the unmatched population, there were no significant differences in overall survival (OS) (P = 0.197) and cause-specific survival (CSS) (P = 0.379) between the PORT and non-PORT groups. After propensity score matching, the patients treated with PORT had longer median OS (P = 0.012) and CSS (P = 0.039) than the non-PORT group. In propensity-adjusted multivariate analysis, non-receipt of PORT was a poor prognostic factor in OS (hazard ratio [HR] 1.39, 95 % confidence interval [CI] 1.08-1.79), and CSS (HR 1.31, 95 % CI 1.01-1.71). The log odds of positive lymph nodes (LOODS) (a parts per thousand yena'0.73) was also associated with worse OS (P = 0.003) and CSS (P = 0.001). In left-sided pancreatic cancer, considering the addition of PORT is a reasonable option as in pancreatic head cancer. The LOODS was suggested as a strong predictive indicator of the patients' prognoses.
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DOI
10.1007/s11605-015-2941-x
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의과대학 > 의학과 > Journal papers
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