View : 205 Download: 0

Rubus occidentalis analgesic effect in a rat model of incisional pain

Title
Rubus occidentalis analgesic effect in a rat model of incisional pain
Authors
Choi, Geun JooKang, HyunKim, Won JoongKwon, Ji WungKim, Beom GyuChoi, Yoo ShinCha, Young JooKo, Jin Soo
Ewha Authors
김원중
SCOPUS Author ID
김원중scopus
Issue Date
2016
Journal Title
JOURNAL OF SURGICAL RESEARCH
ISSN
0022-4804JCR Link

1095-8673JCR Link
Citation
JOURNAL OF SURGICAL RESEARCH vol. 206, no. 1, pp. 223 - 230
Keywords
PainPostoperativeRaspberryRubus
Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
Indexed
SCIE; SCOPUS WOS
Document Type
Article
Abstract
Background: The purpose of this study was to evaluate the analgesic effect of Rubus occidentalis extract (ROE) in a rat model of incisional pain. The involved mechanisms and proinflammatory cytokine response were also examined. Materials and methods: To investigate the analgesic effect, rats were intraperitoneally administered with normal saline or various doses of ROE before or after a plantar incision. To evaluate the involved mechanism, rats were intraperitoneally administered yohimbine, dexmedetomidine, prazosin, naloxone, atropine, or mecamylamine after a plantar incision; ROE was then administered intraperitoneally. The mechanical withdrawal threshold (MWT) was tested with von Frey filaments at various time points. To determine the inflammatory response, serum levels of interleukin (IL)-1 beta or IL-6 were measured. Results: The MWTs significantly increased at 15 min after postincisional administration of 300 mg/kg ROE when compared with those in the control group. This elevation was observed for up to 45 min. Overall, MWTs increased in proportion to ROE dosage; however, ROEs administered before the incision produced no significant change in the MWT. The analgesic effect of ROE was significantly antagonized by mecamylamine, naloxone, and yohimbine, and agonized by dexmedetomidine. Administration of ROE inhibited the postincisional increase in serum IL-1 beta and IL-6. Conclusions: Intraperitoneal administration of ROE after surgery induces antinociceptive effects in a rat model of postoperative pain, and its effects on mechanical hyperalgesia may be associated with alpha(2)-adrenergic, nicotinic cholinergic, and opioid receptors. (C) 2016 Elsevier Inc. All rights reserved.
Show the fulltext
DOI
10.1016/j.jss.2016.08.005
Appears in Collections:
의과대학 > 의학과 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE