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The sul1 Gene in Stenotrophomonas maltophilia With High-Level Resistance to Trimethoprim/Sulfamethoxazole
- The sul1 Gene in Stenotrophomonas maltophilia With High-Level Resistance to Trimethoprim/Sulfamethoxazole
- Chung, Hae-Sun; Kim, Kyeongmi; Hong, Sang Sook; Hong, Seong Geun; Lee, Kyungwon; Chong, Yunsop
- Ewha Authors
- SCOPUS Author ID
- Issue Date
- Journal Title
- ANNALS OF LABORATORY MEDICINE
- ANNALS OF LABORATORY MEDICINE vol. 35, no. 2, pp. 246 - 249
- Stenotrophomonas maltophilia; Trimethoprim/sulfamethoxazole; sul; Class 1 integron
- KOREAN SOC LABORATORY MEDICINE
- SCIE; SCOPUS; KCI
- Document Type
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- Emerging resistance to trimethoprim/sulfamethoxazole (SXT) poses a serious threat to the treatment of Stenotrophomonas maltophilia infections. We determined the prevalence and molecular characteristics of acquired SXT resistance in recent clinical S. maltophilia isolates obtained from Korea. A total of 252 clinical isolates of S. maltophilia were collected from 10 university hospitals in Korea between 2009 and 2010. Antimicrobial susceptibility was determined by using the CLSI agar dilution method. The sul1, sul2, and sul3 genes, integrons, insertion sequence common region (ISCR) elements, and dfrA genes were detected using PCR. The presence of the sul1 gene and integrons was confirmed through sequence analysis. Among the 32 SXT-resistant isolates, sun was detected in 23 isolates (72%), all of which demonstrated high-level resistance (>= 64 mg/L) to SXT. The sun gene (varying in size and structure).was linked to class 1 integrons in 15 of the 23 isolates (65%) harboring this gene. None of the SXT-susceptible isolates or the SXT-resistant isolates with a minimum inhibitory concentration of 4 and 8 mg/L were positive for still. Moreover, the sul2,sul3, and dfrA genes or the ISCR elements were not detected. The sul1 gene may play an important role in the high-level SXT resistance observed in S. maltophilia.
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