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Clinical Usefulness of the 2010 Clinical and Laboratory Standards Institute Revised Breakpoints for Cephalosporin Use in the Treatment of Bacteremia Caused by Escherichia coli or Klebsiella spp.

Title
Clinical Usefulness of the 2010 Clinical and Laboratory Standards Institute Revised Breakpoints for Cephalosporin Use in the Treatment of Bacteremia Caused by Escherichia coli or Klebsiella spp.
Authors
Ku, Nam SuChung, Hae-SunChoi, Jun YongYong, DongeunLee, KyungwonKim, June MyungChong, Yunsop
Ewha Authors
정혜선
SCOPUS Author ID
정혜선scopus
Issue Date
2015
Journal Title
BIOMED RESEARCH INTERNATIONAL
ISSN
2314-6133JCR Link

2314-6141JCR Link
Citation
BIOMED RESEARCH INTERNATIONAL
Publisher
HINDAWI PUBLISHING CORPORATION
Indexed
SCIE; SCOPUS WOS
Document Type
Article
Abstract
We investigated the clinical usefulness of the revised 2010 Clinical and Laboratory Standards Institute (CLSI) breakpoints for Escherichia coli and Klebsiella spp. Of 2,623 patients with bacteremia caused by E. coli or Klebsiella spp., 573 who had been treated appropriately with cephalosporin based on the CLSI 2009 guidelines were enrolled. There were no differences in the rates of treatment failure or mortality between the appropriately and inappropriately treated groups according to the CLSI 2010 guidelines. Additionally, in the matched case-control analysis, the treatment failure rate was higher in bacteremic patients with extended spectrum beta-lactamase-(ESBL-) producing but cephalosporin-susceptible organisms than in those with ESBL-nonproducing isolates when patients with urinary tract infections were excluded (44% and 0%, resp., P = 0.026). In patients with bacteremia caused by E. coli or Klebsiella spp., the revised CLSI 2010 guidelines did not lead to poorer outcomes. However, ESBL production appeared to be associated with poor clinical outcomes in patients with bacteremia from sources other than the urinary tract.
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DOI
10.1155/2015/831074
Appears in Collections:
의과대학 > 의학과 > Journal papers
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