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dc.contributor.author남상집-
dc.date.accessioned2019-11-05T16:30:15Z-
dc.date.available2019-11-05T16:30:15Z-
dc.date.issued2019-
dc.identifier.issn0022-3263-
dc.identifier.issn1520-6904-
dc.identifier.otherOAK-25570-
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/251775-
dc.description.abstractGlutamate neurotoxicity has been implicated in neuronal death in both acute CNS injury and in chronic neurodegenerative diseases. Five unique cyclic depsipeptides with neuroprotective activity, colletotrichamides A-E (1-5), were isolated from cultures of a halophyte Suaeda japonica-associated fungus, Colletotrichum gloeosporioides JS419. Spectroscopic analysis revealed that they were glycosylated cyclic lipodepsipeptides. Their relative configurations were determined by ROESY and J-based configuration analysis, and absolute configurations were established by chemical reactions including modified Mosher's method, advanced Marfey's method, and sugar derivatization. This is the first report of a glycosylated dimethyl-trioxygenated dodecanoyl moiety, and the relative as well as absolute stereochemistry was elucidated herein for the first time. Colletotrichamide C exhibited strong neuroprotective activity against glutamate in hippocampal HT22 cells.-
dc.languageEnglish-
dc.publisherAMER CHEMICAL SOC-
dc.titleNeuroprotective Glycosylated Cyclic Lipodepsipeptides, Colletotrichamides A-E, from a Halophyte-Associated Fungus, Colletotrichum gloeosporioides JS419-
dc.typeArticle-
dc.relation.issue17-
dc.relation.volume84-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage10999-
dc.relation.lastpage11006-
dc.relation.journaltitleJOURNAL OF ORGANIC CHEMISTRY-
dc.identifier.doi10.1021/acs.joc.9b01511-
dc.identifier.wosidWOS:000485089200043-
dc.author.googleBang, Sunghee-
dc.author.googleLee, Changyeol-
dc.author.googleKim, Soonok-
dc.author.googleSong, Ji Hoon-
dc.author.googleKang, Ki Sung-
dc.author.googleDeyrup, Stephen T.-
dc.author.googleNam, Sang-Jip-
dc.author.googleXia, Xuekui-
dc.author.googleShim, Sang Hee-
dc.contributor.scopusid남상집(57208839798;36455982300)-
dc.date.modifydate20210915112221-
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자연과학대학 > 화학·나노과학전공 > Journal papers
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