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Synthesis of 1,2,3-Triazolium Ionic Liquid-Supported Chiral Imidazolidinones and Their Application in Asymmetric Alkylation Reaction

Title
Synthesis of 1,2,3-Triazolium Ionic Liquid-Supported Chiral Imidazolidinones and Their Application in Asymmetric Alkylation Reaction
Authors
Jeong, YunkyungPark, YunjeongRyu, Jae-Sang
Ewha Authors
류재상박윤정
SCOPUS Author ID
류재상scopus
Issue Date
2019
Journal Title
MOLECULES
ISSN
1420-3049JCR Link
Citation
MOLECULES vol. 24, no. 18
Keywords
ionic liquid1,2,3-triazoliumchiral imidazolidinoneasymmetric alkylationchiral auxiliaries
Publisher
MDPI
Indexed
SCIE; SCOPUS WOS
Document Type
Article
Abstract
New 1,2,3-triazolium ionic liquid-supported chiral imidazolidinones were developed. The feasibility of the ionic liquid-supported imidazolidinones as chiral auxiliaries was demonstrated in sequential propionylation-alkylation-cleavage reactions, which provided the chiral product with good to excellent chemical yields (up to 90%) and high selectivities (up to 94% ee). The progress of the reactions could be monitored by TLC and NMR, and the ionic liquid-supported chiral auxiliaries could be recovered by simple extraction.
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DOI
10.3390/molecules24183349
Appears in Collections:
약학대학 > 약학과 > Journal papers
Files in This Item:
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