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Concise Review: Application of Tonsil-Derived Mesenchymal Stem Cells in Tissue Regeneration

Title
Concise Review: Application of Tonsil-Derived Mesenchymal Stem Cells in Tissue Regeneration
Authors
Oh, Se-YoungChoi, Young MinKim, Ha YeongPark, Yoon ShinJung, Sung-ChulPark, Joo-WonWoo, So-YounRyu, Kyung-HaKim, Han SuJo, Inho
Ewha Authors
유경하우소연김한수정성철조인호박주원오세영
SCOPUS Author ID
유경하scopus; 우소연scopus; 김한수scopus; 정성철scopus; 조인호scopus; 박주원scopus; 오세영scopus
Issue Date
2019
Journal Title
STEM CELLS
ISSN
1066-5099JCR Link

1549-4918JCR Link
Citation
STEM CELLS vol. 37, no. 10, pp. 1252 - 1260
Keywords
Mesenchymal stem cellsDifferentiationTissue engineeringRegenerative medicineImmunomodulation
Publisher
WILEY
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Review
Abstract
Since the discovery of stem cells and multipotency characteristics of mesenchymal stem cells (MSCs), there has been tremendous development in regenerative medicine. MSCs derived from bone marrow have been widely used in various research applications, yet there are limitations such as invasiveness of obtaining samples, low yield and proliferation rate, and questions regarding their practicality in clinical applications. Some have suggested that MSCs from other sources, specifically those derived from palatine tonsil tissues, that is, tonsil-derived MSCs (TMSCs), could be considered as a new potential therapeutic tool in regenerative medicine due to their superior proliferation rate and differentiation capabilities with low immunogenicity and ease of obtaining. Several studies have determined that TMSCs have differentiation potentials not only into the mesodermal lineage but also into the endodermal as well as ectodermal lineages, expanding their potential usage and placing them as an appealing option to consider for future studies in regenerative medicine. In this review, the differentiation capacities of TMSCs and their therapeutic competencies from past studies are addressed. Stem Cells 2019
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DOI
10.1002/stem.3058
Appears in Collections:
의과대학 > 의학과 > Journal papers
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