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Bioenzymatic and Chemical Derivatization of Renewable Fatty Acids

Title
Bioenzymatic and Chemical Derivatization of Renewable Fatty Acids
Authors
Akula, Ravi KumarKwon, Yong-Uk
Ewha Authors
권용억
SCOPUS Author ID
권용억scopus
Issue Date
2019
Journal Title
BIOMOLECULES
ISSN
2218-273XJCR Link
Citation
BIOMOLECULES vol. 9, no. 10
Keywords
omega-amino acidbiocatalysisbiomassalpha,omega-dicarboxylic acidfatty acidoxidation
Publisher
MDPI
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
In addition to our previous efforts toward bioenzymatic and chemical transformations of ricinoleic acid and oleic acid to their corresponding alpha,omega-dicarboxylic acids via their ester intermediates driven in Escherichia coli cells, several efficient oxidation conditions were investigated and optimized for the conversion of omega-hydroxycarboxylic acids to alpha,omega-dicarboxylic acids. Pd/C-catalyzed oxidation using NaBH4 in a basic aqueous alcohol and Ni(II) salt-catalyzed oxidation using aqueous sodium hypochlorite were considered to be excellent as a hybrid reaction for three successive chemical reactions (hydrogenation, hydrolysis, and oxidation) and an eco-friendly, cost-effective, and practical approach, respectively. Omega-hydroxycarboxylic acids and omega-aminocarboxylic acid were also easily prepared as useful building blocks for plastics or bioactive compounds from the bioenzymatically driven ester intermediate. The scope of the developed synthetic methods can be utilized for large-scale synthesis and various derivatizations.
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DOI
10.3390/biom9100566
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자연과학대학 > 화학·나노과학전공 > Journal papers
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