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Targeting Heat Shock Protein 27 in Cancer: A Druggable Target for Cancer Treatment?
- Title
- Targeting Heat Shock Protein 27 in Cancer: A Druggable Target for Cancer Treatment?
- Authors
- Choi, Seul-Ki; Kam, Heejin; Kim, Kye-Young; Park, Suk In; Lee, Yun-Sil
- Ewha Authors
- 이윤실
- SCOPUS Author ID
- 이윤실
- Issue Date
- 2019
- Journal Title
- CANCERS
- ISSN
- 2072-6694
- Citation
- CANCERS vol. 11, no. 8
- Keywords
- heat shock protein 27; HSP27 inhibitor; anti-cancer drugs; resistance
- Publisher
- MDPI
- Indexed
- SCIE; SCOPUS
- Document Type
- Review
- Abstract
- Heat shock protein 27 (HSP27), induced by heat shock, environmental, and pathophysiological stressors, is a multi-functional protein that acts as a protein chaperone and an antioxidant. HSP27 plays a significant role in the inhibition of apoptosis and actin cytoskeletal remodeling. HSP27 is upregulated in many cancers and is associated with a poor prognosis, as well as treatment resistance, whereby cells are protected from therapeutic agents that normally induce apoptosis. This review highlights the most recent findings and role of HSP27 in cancer, as well as the strategies for using HSP27 inhibitors for therapeutic purposes.
- DOI
- 10.3390/cancers11081195
- Appears in Collections:
- 약학대학 > 약학과 > Journal papers
- Files in This Item:
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Targeting Heat Shock Protein 27 in Cancer.pdf(2.56 MB)
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