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dc.contributor.author박예원-
dc.date.accessioned2019-10-02T02:00:04Z-
dc.date.available2019-10-02T02:00:04Z-
dc.date.issued2019-
dc.identifier.issn1229-6929-
dc.identifier.issn2005-8330-
dc.identifier.otherOAK-25377-
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/251511-
dc.description.abstractObjective: To assess whether radiomics features derived from multiparametric MRI can predict the tumor grade of lower-grade gliomas (LGGs; World Health Organization grade II and grade III) and the nonenhancing LGG subgroup. Materials and Methods: Two-hundred four patients with LGGs from our institutional cohort were allocated to training (n = 136) and test (n = 68) sets. Postcontrast T1-weighted images, T2-weighted images, and fluid-attenuated inversion recovery images were analyzed to extract 250 radiomics features. Various machine learning classifiers were trained using the radiomics features to predict the glioma grade. The trained classifiers were internally validated on the institutional test set and externally validated on a separate cohort (n = 99) from The Cancer Genome Atlas (TCGA). Classifier performance was assessed by determining the area under the curve (AUC) from receiver operating characteristic curve analysis. An identical process was performed in the nonenhancing LGG subgroup (institutional training set, n = 73; institutional test set, n = 37; and TCGA cohort, n = 37) to predict the glioma grade. Results: The performance of the best classifier was good in the internal validation set (AUC, 0.85) and fair in the external validation set (AUC, 0.72) to predict the LGG grade. For the nonenhancing LGG subgroup, the performance of the best classifier was good in the internal validation set (AUC, 0.82), but poor in the external validation set (AUC, 0.68). Conclusion: Radiomics feature-based classifiers may be useful to predict LGG grades. However, radiomics classifiers may have a limited value when applied to the nonenhancing LGG subgroup in a TCGA cohort.-
dc.languageEnglish-
dc.publisherKOREAN RADIOLOGICAL SOC-
dc.subjectGrade-
dc.subjectLower-grade glioma-
dc.subjectMagnetic resonance imaging-
dc.subjectRadiomics-
dc.subjectThe Cancer Genome Atlas-
dc.titleRadiomics MRI Phenotyping with Machine Learning to Predict the Grade of Lower-Grade Gliomas: A Study Focused on Nonenhancing Tumors-
dc.typeArticle-
dc.relation.issue9-
dc.relation.volume20-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.indexKCI-
dc.relation.startpage1381-
dc.relation.lastpage1389-
dc.relation.journaltitleKOREAN JOURNAL OF RADIOLOGY-
dc.identifier.doi10.3348/kjr.2018.0814-
dc.identifier.wosidWOS:000483930900006-
dc.identifier.scopusid2-s2.0-85071636365-
dc.author.googlePark, Yae Won-
dc.author.googleChoi, Yoon Seong-
dc.author.googleAhn, Sung Soo-
dc.author.googleChang, Jong Hee-
dc.author.googleKim, Se Hoon-
dc.author.googleLee, Seung-Koo-
dc.date.modifydate20200326081001-
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의료원 > 의료원 > Journal papers
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