Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김희선 | * |
dc.contributor.author | 임예현 | * |
dc.date.accessioned | 2019-10-02T01:59:59Z | - |
dc.date.available | 2019-10-02T01:59:59Z | - |
dc.date.issued | 2019 | * |
dc.identifier.issn | 0306-4530 | * |
dc.identifier.other | OAK-25342 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/251476 | - |
dc.description.abstract | Repeated or chronic stressful stimuli induce emotion- and mood-related abnormalities, such as anxiety and depression. Conversely, regular exercise exerts protective effects. Here, we found that exercise recovered anxiety-like behaviors, as measured using the open field and elevated plus maze tests in an anxiety mouse model. In addition to behavioral improvement, exercise enhanced the synaptic density of the 5-hydroxytryptamine 2A receptor (5-HT2AR), but not the 5-HT1AR in the basolateral amygdala (BLA) region in this mouse model. Furthermore, global treatment with a selective 5-HT2AR antagonist (MDL11930) generated an anxiety phenotype. Thus, synaptic recruitment of 5-HT2AR in BLA neurons may mediate the anxiolytic effects of exercise. The exercise regimen also reduced adenosine A(2A) receptor (A(2A)R)-mediated protein kinase A (PKA) activation, and the anxiolytic effect of the exercise was blunted by local activation of A(2A)R within the BLA using CGS21680, a selective A(2A)R agonist. Particularly, A(2A)R-mediated PKA activity was shown to be dependent on 5-HT2AR signaling in the BLA. These results imply that repeated stress upregulates A(2A)R-mediated adenosine signaling to facilitate PKA activation, whereas regular exercise inhibits A(2A)R function by increasing 5-HT2AR in the BLA. Accordingly, this integrated modulation of 5-HT and adenosine signaling, via 5-HT2AR and A(2A)R respectively, may be a mechanism underlying the anxiolytic effect of regular exercise. | * |
dc.language | English | * |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | * |
dc.subject | Repeated stress | * |
dc.subject | Anxiety | * |
dc.subject | Exercise 5-HT2A receptor | * |
dc.subject | Adenosine A(2A) receptor | * |
dc.subject | Basolateral amygdala | * |
dc.title | Exercise exerts an anxiolytic effect against repeated restraint stress through 5-HT2A-mediated suppression of the adenosine A(2A) receptor in the basolateral amygdala | * |
dc.type | Article | * |
dc.relation.volume | 108 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 182 | * |
dc.relation.lastpage | 189 | * |
dc.relation.journaltitle | PSYCHONEUROENDOCRINOLOGY | * |
dc.identifier.doi | 10.1016/j.psyneuen.2019.06.005 | * |
dc.identifier.wosid | WOS:000484870800023 | * |
dc.identifier.scopusid | 2-s2.0-85067645614 | * |
dc.author.google | Leem, Yea-Hyun | * |
dc.author.google | Jang, Jee-Hun | * |
dc.author.google | Park, Jin-Sun | * |
dc.author.google | Kim, Hee-Sun | * |
dc.contributor.scopusid | 김희선(57191372551) | * |
dc.contributor.scopusid | 임예현(25422269100) | * |
dc.date.modifydate | 20240222143226 | * |