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Serum anti-GAPDH autoantibody levels reflect the severity of cervical lesions: A potential serum biomarker for cervical cancer screening

Title
Serum anti-GAPDH autoantibody levels reflect the severity of cervical lesions: A potential serum biomarker for cervical cancer screening
Authors
Xu, Mei LingKim, Hyoung JinKim, Seung CheolJu, WoongKim, Yun HwanChang, Kyu-HoKim, Hong-Jin
Ewha Authors
김승철주웅김윤환
SCOPUS Author ID
김승철scopus; 주웅scopus; 김윤환scopus
Issue Date
2019
Journal Title
ONCOLOGY LETTERS
ISSN
1792-1074JCR Link

1792-1082JCR Link
Citation
ONCOLOGY LETTERS vol. 18, no. 1, pp. 255 - 264
Keywords
autoantibodyglyceraldehyde 3-phosphate dehydrogenasecervical cancercervical intraepithelial neoplasiaserum biomarker
Publisher
SPANDIDOS PUBL LTD
Indexed
SCIE; SCOPUS WOS
Document Type
Article
Abstract
Recent studies have indicated that a certain level of autoantibodies may be essential for maintaining good health as well as preventing cancer development, and that the levels of serum autoantibodies can decline during malignant progression. The aim of the present study was to identify such an autoantibody-based biomarker for screening cervical lesions. An autoantigen reactive with healthy female sera was detected in the cytosolic fraction of HeLa cells, a cervical cancer cell line, and identified. Serum immunoglobulin (Ig)-G and IgM levels against the purified autoantigen in normal, cervical intraepithelial neoplasias (CINs) I, II and III, and cervical cancer were compared using ELISAs. The autoantigen in HeLa cells was identified to be GAPDH. The serum levels of anti-HeLa-GAPDH IgG decreased with increasing severity of cervical lesions, and similar decreases in IgM levels were revealed. Notably, the anti-HeLa-GAPDH IgG level was discovered to discriminate cervical cancer from normal samples with 80.0% sensitivity and 96.6% specificity. The serum anti-HeLa-GAPDH autoantibody level, as a single parameter, is a promising serum biomarker for screening cervical lesions.
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DOI
10.3892/ol.2019.10326
Appears in Collections:
의과대학 > 의학과 > Journal papers
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