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Application of Size and Maturation Functions to Population Pharmacokinetic Modeling of Pediatric Patients

Title
Application of Size and Maturation Functions to Population Pharmacokinetic Modeling of Pediatric Patients
Authors
Back, Hyun-moonLee, Jong BongHan, NayoungGoo, SungwooJung, EbenKim, JunyeongSong, ByungjeongAn, Sook HeeKim, Jung TaeRhie, Sandy JeongRee, Yoon SunChae, Jung-wooKim, JaeWooYun, Hwi-yeol
Ewha Authors
이정연
SCOPUS Author ID
이정연scopus
Issue Date
2019
Journal Title
PHARMACEUTICS
ISSN
1999-4923JCR Link
Citation
PHARMACEUTICS vol. 11, no. 6
Keywords
size functionmaturation functionpharmacometricspediatricscyclosporinphenobarbitalvancomycin
Publisher
MDPI
Indexed
SCIE; SCOPUS WOS
Document Type
Article
Abstract
Traditionally, dosage for pediatric patients has been optimized using simple weight-scaled methods, but these methods do not always meet the requirements of children. To overcome this discrepancy, population pharmacokinetic (PK) modeling of size and maturation functions has been proposed. The main objective of the present study was to evaluate a new modeling method for pediatric patients using clinical data from three different clinical studies. To develop the PK models, a nonlinear mixed effect modeling method was employed, and to explore PK differences in pediatric patients, size with allometric and maturation with Michaelis-Menten type functions were evaluated. Goodness of fit plots, visual predictive check and bootstrap were used for model evaluation. Single application of size scaling to PK parameters was statistically significant for the over one year old group. On the other hand, simultaneous use of size and maturation functions was statistically significant for infants younger than one year old. In conclusion, population PK modeling for pediatric patients was successfully performed using clinical data. Size and maturation functions were applied according to established criteria, and single use of size function was applicable for over one year ages, while size and maturation functions were more effective for PK analysis of neonates and infants.
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DOI
10.3390/pharmaceutics11060259
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약학대학 > 약학과 > Journal papers
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