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Mycousfurans A and B, antibacterial usnic acid congeners from the fungus Mycosphaerella sp., isolated from a marine sediment

Title
Mycousfurans A and B, antibacterial usnic acid congeners from the fungus Mycosphaerella sp., isolated from a marine sediment
Authors
Lee J.Kim G.J.Yang I.Wang W.Nam J.-W.Choi H.Nam S.-J.Kang H.
Ewha Authors
남상집
SCOPUS Author ID
남상집scopusscopus
Issue Date
2019
Journal Title
Marine Drugs
ISSN
1660-3397JCR Link
Citation
Marine Drugs vol. 17, no. 7
Keywords
Antibacterial activityMycosphaerella spMycousfuransMycousninePlacodiolic acidUsnic acid
Publisher
MDPI AG
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Mycousfurans (1 and 2), two new usnic acid congeners, along with (−)-mycousnine (3), (−)-placodiolic acid (4), and (+)-usnic acid (5), were isolated using high-performance liquid chromatography-ultraviolet (HPLC-UV)-guided fractionation of extracts of Mycosphaerella sp. isolated from a marine sediment. The planar structures of 1 and 2 were elucidated using 1D and 2D NMR spectra. The relative configurations of the stereogenic carbons of 1 and 2 were established via analysis of their nuclear Overhauser spectroscopy (NOESY) spectra, and their absolute configurations were determined using a comparison of experimental and calculated electronic circular dichroism (ECD) spectra. Compounds 1 and 2 were found to have antibacterial activity, showing moderate activity against Kocuria rhizophila and Staphylococcus aureus. © 2019 by the authors.
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DOI
10.3390/md17070422
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자연과학대학 > 화학·나노과학전공 > Journal papers
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