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Progress toward a group B streptococcal vaccine

Title
Progress toward a group B streptococcal vaccine
Authors
Song, Joon YoungLim, Jae HyangLim, SangyongYong, ZhiSeo, Ho Seong
Ewha Authors
임재향
SCOPUS Author ID
임재향scopus
Issue Date
2018
Journal Title
HUMAN VACCINES & IMMUNOTHERAPEUTICS
ISSN
2164-5515JCR Link

2164-554XJCR Link
Citation
HUMAN VACCINES & IMMUNOTHERAPEUTICS vol. 14, no. 11, pp. 2669 - 2681
Keywords
group B Streptococcusmaternal immunizationStreptococcus agalactiaevaccine
Publisher
TAYLOR &

FRANCIS INC
Indexed
SCIE; SCOPUS WOS
Document Type
Review
Abstract
Streptococcus agalactiae (group B Streptococcus, GBS) is a leading cause of severe invasive disease in neonate, elderly, and immunocompromised patients worldwide. Despite recent advances in the diagnosis and intrapartum antibiotic prophylaxis (IAP) of GBS infections, it remains one of the most common causes of neonatal morbidity and mortality, causing serious infections. Furthermore, recent studies reported an increasing number of GBS infections in pregnant women and elderly. Although IAP is effective, it has several limitations, including increasing antimicrobial resistance and late GBS infection after negative antenatal screening. Maternal immunization is the most promising and effective countermeasure against GBS infection in neonates. However, no vaccine is available to date, but two types of vaccines, protein subunit and capsular polysaccharide conjugate vaccines, were investigated in clinical trials. Here, we provide an overview of the GBS vaccine development status and recent advances in the development of immunoassays to evaluate the GBS vaccine clinical efficacy.
DOI
10.1080/21645515.2018.1493326
Appears in Collections:
의과대학 > 의학과 > Journal papers
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