Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 한평림 | - |
dc.contributor.author | 김윤근 | - |
dc.date.accessioned | 2019-07-29T16:30:06Z | - |
dc.date.available | 2019-07-29T16:30:06Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 1226-2560 | - |
dc.identifier.issn | 2093-8144 | - |
dc.identifier.other | OAK-25150 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/250195 | - |
dc.description.abstract | Gut microbiota play a role in regulating mental disorders, but the mechanism by which gut microbiota regulate brain function remains unclear. Gram negative and positive gut bacteria release membrane-derived extracellular vesicles (EVs), which function in microbiota-host intercellular communication. In the present study, we investigated whether Lactobacillus plantarum derived EVs (L-EVs) could have a role in regulating neuronal function and stress-induced depressive-like behaviors. HT22 cells treated with the stress hormone glucocorticoid (GC; corticosterone) had reduced expression of Bdnf and Sirt1, whereas L -EV treatment reversed GC-induced decreased expression of Bdnf and Sirt1. The siRNA-mediated knockdown of Sirt1 in HT22 cells decreased Bdnf4, a splicing variant of Bdnf, and Creb expression, suggesting that Sirt1 plays a role in L -EV-induced increase of BDNF and CREB expression. Mice exposed to restraint for 2-h daily for 14 days (CRST) exhibited depressive-like behaviors, and these CRST-treated mice had reduced expression of Bdnf and Nt4/5 in the hippocampus. In contrast, L-EV injection prior to each restraint treatment blocked the reduced expression of Bdnf and Nt4/5, and stress-induced depressive-like behaviors. Furthermore, L-EV treatment in CRST-treated mice also rescued the reduced expression of Bdnf, and blocked stress-induced depressive-like behaviors. These results suggest that Lactobacillus derived EVs can change the expression of neurotropic factors in the hippocampus and afford antidepressant-like effects in mice with stress-induced depression. | - |
dc.language | English | - |
dc.publisher | KOREAN SOC BRAIN & | - |
dc.publisher | NEURAL SCIENCE, KOREAN SOC NEURODEGENERATIVE DISEASE | - |
dc.subject | Extracellular vesicles | - |
dc.subject | Lactobacillus plantarum | - |
dc.subject | BDNF | - |
dc.subject | Antidepressant-like effects | - |
dc.title | Extracellular Vesicles Derived from Lactobacillus plantarum Increase BDNF Expression in Cultured Hippocampal Neurons and Produce Antidepressant-like Effects in Mice | - |
dc.type | Article | - |
dc.relation.issue | 2 | - |
dc.relation.volume | 28 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.index | KCI | - |
dc.relation.startpage | 158 | - |
dc.relation.lastpage | 171 | - |
dc.relation.journaltitle | EXPERIMENTAL NEUROBIOLOGY | - |
dc.identifier.doi | 10.5607/en.2019.28.2.158 | - |
dc.identifier.wosid | WOS:000468151200004 | - |
dc.author.google | Choi, Juli | - |
dc.author.google | Kim, Yoon-Keun | - |
dc.author.google | Han, Pyung-Lim | - |
dc.contributor.scopusid | 한평림(7201947605) | - |
dc.contributor.scopusid | 김윤근(7410211755;7410198224) | - |
dc.date.modifydate | 20230901081001 | - |