Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 서은경 | * |
dc.date.accessioned | 2019-07-22T16:30:21Z | - |
dc.date.available | 2019-07-22T16:30:21Z | - |
dc.date.issued | 2019 | * |
dc.identifier.issn | 1422-0067 | * |
dc.identifier.other | OAK-25010 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/250115 | - |
dc.description.abstract | Skullcapflavone II is a flavonoid derived from the root of Scutellaria baicalensis, a herbal medicine used for anti-inflammatory and anti-cancer therapies. We analyzed the effect of skullcapflavone II on the expression of matrix metalloproteinase-1 (MMP-1) and integrity of type I collagen in foreskin fibroblasts. Skullcapflavone II did not affect the secretion of type I collagen but reduced the secretion of MMP-1 in a dose- and time-dependent manner. Real-time reverse transcription-PCR and reporter gene assays showed that skullcapflavone II reduced MMP-1 expression at the transcriptional level. Skullcapflavone II inhibited the serum-induced activation of the extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) signaling pathways required for MMP-1 transactivation. Skullcapflavone II also reduced tumor necrosis factor (TNF)--induced nuclear factor kappa light chain enhancer of activated B cells (NF-B) activation and subsequent MMP-1 expression. In three-dimensional culture of fibroblasts, skullcapflavone II down-regulated TNF--induced MMP-1 secretion and reduced breakdown of type I collagen. These results indicate that skullcapflavone II is a novel biomolecule that down-regulates MMP-1 expression in foreskin fibroblasts and therefore could be useful in therapies for maintaining the integrity of extracellular matrix. | * |
dc.language | English | * |
dc.publisher | MDPI | * |
dc.subject | extracellular matrix | * |
dc.subject | fibroblast | * |
dc.subject | inflammation | * |
dc.subject | MMP-1 | * |
dc.subject | skullcapflavone II | * |
dc.subject | type I collagen | * |
dc.title | Skullcapflavone II Inhibits Degradation of Type I Collagen by Suppressing MMP-1 Transcription in Human Skin Fibroblasts | * |
dc.type | Article | * |
dc.relation.issue | 11 | * |
dc.relation.volume | 20 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | * |
dc.identifier.doi | 10.3390/ijms20112734 | * |
dc.identifier.wosid | WOS:000472634100128 | * |
dc.author.google | Lee, Young Hun | * |
dc.author.google | Seo, Eun Kyoung | * |
dc.author.google | Lee, Seung-Taek | * |
dc.contributor.scopusid | 서은경(7005953758) | * |
dc.date.modifydate | 20240118144717 | * |