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Inhibition of Karyopherin-2 Augments Radiation-Induced Cell Death by Perturbing BRCA1-Mediated DNA Repair
- Title
- Inhibition of Karyopherin-2 Augments Radiation-Induced Cell Death by Perturbing BRCA1-Mediated DNA Repair
- Authors
- Song, Kyung-Hee; Jung, Seung-Youn; Park, Jeong-In; Ahn, Jiyeon; Park, Jong Kuk; Um, Hong-Duck; Park, In-Chul; Hwang, Sang-Gu; Ha, Hunjoo; Song, Jie-Young
- Ewha Authors
- 하헌주
- SCOPUS Author ID
- 하헌주
- Issue Date
- 2019
- Journal Title
- INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- ISSN
- 1422-0067
- Citation
- INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES vol. 20, no. 11
- Keywords
- ionizing radiation; karyopherin-2; DNA repair; radioresistance; BRCA1
- Publisher
- MDPI
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Ionizing radiation (IR) has been widely used in the treatment of cancer. Radiation-induced DNA damage triggers the DNA damage response (DDR), which can confer radioresistance and early local recurrence by activating DNA repair pathways. Since karyopherin-2 (KPNA2), playing an important role in nucleocytoplasmic transport, was significantly increased by IR in our previous study, we aimed to determine the function of KPNA2 with regard to DDR. Exposure to radiation upregulated KPNA2 expression in human colorectal cancer HT29 and HCT116 cells and breast carcinoma MDA-MB-231 cells together with the increased expression of DNA repair protein BRCA1. The knockdown of KPNA2 effectively increased apoptotic cell death via inhibition of BRCA1 nuclear import following IR. Therefore, we propose that KPNA2 is a potential target for overcoming radioresistance via interruption to DDR.
- DOI
- 10.3390/ijms20112843
- Appears in Collections:
- 약학대학 > 약학과 > Journal papers
- Files in This Item:
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