View : 617 Download: 155
Clinical Significance of Lymph-Node Ratio in Determining Supraclavicular Lymph-Node Radiation Therapy in pN1 Breast Cancer Patients Who Received Breast-Conserving Treatment (KROG 14-18): A Multicenter Study
- Title
- Clinical Significance of Lymph-Node Ratio in Determining Supraclavicular Lymph-Node Radiation Therapy in pN1 Breast Cancer Patients Who Received Breast-Conserving Treatment (KROG 14-18): A Multicenter Study
- Authors
- Kim, Jaeho; Park, Won; Kim, Jin Hee; Choi, Doo Ho; Kim, Yeon-Joo; Lee, Eun Sook; Shin, Kyung Hwan; Kim, Jin Ho; Kim, Kyubo; Kim, Yong Bae; Ahn, Sung-Ja; Lee, Jong Hoon; Chun, Mison; Lee, Hyung-Sik; Kim, Jung Soo; Cha, Jihye
- Ewha Authors
- 김규보
- SCOPUS Author ID
- 김규보
- Issue Date
- 2019
- Journal Title
- CANCERS
- ISSN
- 2072-6694
- Citation
- CANCERS vol. 11, no. 5
- Keywords
- breast cancer; radiotherapy; lymph-node ratio; disease-free survival
- Publisher
- MDPI
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- This study evaluated the clinical significance of the lymph-node ratio (LNR) and its usefulness as an indicator of supraclavicular lymph-node radiation therapy (SCNRT) in pN1 breast cancer patients with disease-free survival (DFS) outcomes. We retrospectively analyzed the clinical data of patients with pN1 breast cancer who underwent partial mastectomy and taxane-based sequential adjuvant chemotherapy with postoperative radiation therapy in 12 hospitals (n = 1121). We compared their DFS according to LNR, with a cut-off value of 0.10. The median follow-up period was 66 months (range, 3-112). Treatment failed in 73 patients (6.5%) and there was no significant difference in DFS between the SCNRT group and non-SCNRT group. High LNR (>0.10) showed significantly worse DFS in both univariate and multivariate analyses (0.010 and 0.033, respectively). In a subgroup analysis, the effect of SCNRT on DFS differed significantly among patients with LNR > 0.10 (p = 0.013). High LNR can be used as an independent prognostic factor for pN1 breast cancer patients treated with partial mastectomy and postoperative radiotherapy. It may also be useful in deciding whether to perform SCNRT to improve DFS.
- DOI
- 10.3390/cancers11050680
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
- Files in This Item:
-
Clinical Significance of Lymph-Node Ratio.pdf(472.23 kB)
Download
- Export
- RIS (EndNote)
- XLS (Excel)
- XML