View : 648 Download: 132

Humanized Anti-hepatocyte Growth Factor Monoclonal Antibody (YYB-101) Inhibits Ovarian Cancer Progression

Title
Humanized Anti-hepatocyte Growth Factor Monoclonal Antibody (YYB-101) Inhibits Ovarian Cancer Progression
Authors
Kim, Hyun JungLee, SukmookOh, Yong-SeokChang, Ha KyunKim, Young SangHong, Sung HeeKim, Jung YongPark, Young-WhanLee, Song-JaeSong, Seong-WonKim, Jung JuHeo, Kyun
Ewha Authors
김현정
Issue Date
2019
Journal Title
FRONTIERS IN ONCOLOGY
ISSN
2234-943XJCR Link
Citation
FRONTIERS IN ONCOLOGY vol. 9
Keywords
HGFhumanized monoclonal antibodyovarian cancermetastasisYYB-101
Publisher
FRONTIERS MEDIA SA
Indexed
SCIE; SCOPUS WOS
Document Type
Article
Abstract
Current chemotherapy regimens have certain limitations in improving the survival rates of patients with advanced ovarian cancer. Hepatocyte growth factor (HGF) is important in ovarian cancer cell migration and invasion. This study assessed the effects of YYB-101, a humanized monoclonal anti-HGF antibody, on the growth and metastasis of ovarian cancer cells. YYB-101 suppressed the phosphorylation of the HGF receptor c-MET and inhibited the migration and invasion of SKOV3 and A2780 ovarian cancer cells. Moreover, the combination of YYB-101 and paclitaxel synergistically inhibited tumor growth in an in vivo ovarian cancer mouse xenograft model and significantly increased the overall survival (OS) rate compared with either paclitaxel or YYB-101 alone. Taken together, these findings suggest that YYB-101 has therapeutic potential in ovarian cancer when combined with conventional chemotherapy agents.
Show the fulltext
DOI
10.3389/fonc.2019.00571
Appears in Collections:
연구기관 > 세포신호전달계바이오의약연구센터 > Journal papers
Files in This Item:
Humanized Anti-hepatocyte.pdf(1.65 MB) Download
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE