JOURNAL OF ORGANIC CHEMISTRY vol. 84, no. 11, pp. 6689 - 6696
Publisher
AMER CHEMICAL SOC
Indexed
SCIE; SCOPUS
Document Type
Article
Abstract
A facile method for the synthesis of N-aryl-substituted azacycles from arylamines and cyclic ethers has been developed. In this study, arylamines were treated with cyclic ethers in the presence of POCI3 and DBU to provide five- and six-membered azacycles. Using this method, various azacycloalkanes, isoindolines, and tetrahydroisoquinolines were prepared in high yields. This synthetic method offers an efficient approach to the production of azacycles from cyclic ethers.