Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 오세관 | * |
dc.contributor.author | 서봉준 | * |
dc.date.accessioned | 2019-06-04T16:30:10Z | - |
dc.date.available | 2019-06-04T16:30:10Z | - |
dc.date.issued | 2019 | * |
dc.identifier.issn | 0360-3997 | * |
dc.identifier.issn | 1573-2576 | * |
dc.identifier.other | OAK-24819 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/249929 | - |
dc.description.abstract | This experiment was conducted to investigate the effects of a benzylideneacetophenone derivative ((2E)-3-(4-hydroxy-3-methoxyphenyl)phenylpro-2-en-l-one (JC3)) on trimellitic anhydride (TMA)-induced atopic dermatitis (AD)-like symptoms in mice. To induce AD, the dorsal skins of mice were treated with 5% TMA on day 0 and both ears were treated with 5% TMA on day 5 and with 2% TMA from day 6 to day 14. JC3 (1, 5, 10mg/kg, i.p.) was treated once daily from day 9 to day 14 before TMA treatment. Histological analysis was performed and auricular lymph node weights, ear thicknesses, skin water contents, scratching behaviors, and serum immunoglobulin (IgE) and IFN-, and interleukin-4 (IL-4) levels in serum and ear tissues were determined. In addition, the anti-AD activity of JC3 was investigated on phorbol 12-myristate 13-acetate (PMA)-stimulated human mast cells (HMC-1 cells) derived from patients. Levels of TNF-, IL-4, and mitogen-activated protein kinase (MAPK) were investigated after treating cultured cells with JC3. Treating mice with JC3 (10mg/kg) significantly decreased ear thicknesses, lymph node weights, skin scores, skin water contents, scratching behavior, and IFN-, IL-4 cytokine levels, and serum IgE levels. Moreover, treatment with JC3 (10mg/kg) significantly decreased serum and ear tissues levels of IFN- and IL-4 in AD mice. Furthermore, treatment with JC3 at 10g/ml reduced TNF- and IL-4 levels and decreased MAPK phosphorylation in the HMC-1 cells. The results of this study provide a molecular basis for developing new therapeutics for the treatment of various inflammatory diseases, such as, eczema, asthma, and AD. | * |
dc.language | English | * |
dc.publisher | SPRINGER/PLENUM PUBLISHERS | * |
dc.subject | atopic dermatitis | * |
dc.subject | benzylideneacetophenone derivative | * |
dc.subject | trimellitic anhydride | * |
dc.subject | interleukin-4 | * |
dc.subject | mitogen-activated protein kinase | * |
dc.title | Alleviation of Atopic Dermatitis Lesions by a Benzylideneacetophenone Derivative via the MAPK Signaling Pathway | * |
dc.type | Article | * |
dc.relation.issue | 3 | * |
dc.relation.volume | 42 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 1093 | * |
dc.relation.lastpage | 1102 | * |
dc.relation.journaltitle | INFLAMMATION | * |
dc.identifier.doi | 10.1007/s10753-019-00971-w | * |
dc.identifier.wosid | WOS:000468517600033 | * |
dc.identifier.scopusid | 2-s2.0-85061179627 | * |
dc.author.google | Sur, Bongjun | * |
dc.author.google | Kang, Seungmin | * |
dc.author.google | Kim, Mijin | * |
dc.author.google | Oh, Seikwan | * |
dc.contributor.scopusid | 오세관(7404103757) | * |
dc.contributor.scopusid | 서봉준(26533542400) | * |
dc.date.modifydate | 20240429140616 | * |