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Results of re-irradiation for pelvic recurrence in anorectal cancer patients
- Title
- Results of re-irradiation for pelvic recurrence in anorectal cancer patients
- Authors
- Park, Younghee; Kim, Kyubo; Park, Hae Jin; Jeong, Seung-Yong; Park, Kyu Joo; Han, Sae-Won; Kim, Tae-You; Chie, Eui Kyu
- Ewha Authors
- 김규보
- SCOPUS Author ID
- 김규보
- Issue Date
- 2019
- Journal Title
- BRITISH JOURNAL OF RADIOLOGY
- ISSN
- 0007-1285
1748-880X
- Citation
- BRITISH JOURNAL OF RADIOLOGY vol. 92, no. 1097
- Publisher
- BRITISH INST RADIOLOGY
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Objective: To evaluate outcomes and toxicity profiles after re-irradiation in patients with pelvic recurrence of anorectal cancer. Methods: 25 anorectal cancer patients who received re-irradiation for pelvic recurrence between 2005 and 2015 were included. For initial treatment, all patients underwent surgical resection and preoperative or postoperative radiotherapy. Results: The median follow-up duration was 21.5 months (range, 2.9-84.4). After a median of 43.3 months (range, 11.7-218.5), patients received re-irradiation with a median dose of 45Gy (range, 36-60). The equivalent dose in 2Gy fractions (EQD2) of re-irradiation-calculated using alpha/beta = 10Gy-ranged from 34.5 to 84.0 Gy (median, 46.4). Surgical resection was performed for 11 patients, and 14 patients received concurrent chemotherapy with re-irradiation. The 3-year local progression-free survival was 29.7%. The 3-year overall survival was 49.7%. Concurrent chemotherapy with re-irradiation and re-irradiation doses >5OGy EQD2(alpha/beta=10) were significant prognostic factors for local progression free survival and overall survival according to multivariate analysis. 90% (9 of 10) of patients with symptoms had improvement after re-irradiation. Among 23 patients available for evaluation of late toxicity, 12 developed late toxicities. There were no Grade 4 late toxicities, and 6 patients had Grade 3 late toxicities (small bowel obstruction, bowel perforation and fistula). Conclusion: Re-irradiation for pelvic recurrence of anorectal cancer improved symptoms of patients but the rate of late toxicity was high. Further investigation for patient selection is required. Advances in knowledge: Re-irradiation could be considered as a possible option for pelvic recurrence of anorectal cancer in selected patients.
- DOI
- 10.1259/bjr.20180794
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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