View : 918 Download: 0
Degranulated Eosinophils Contain More Fine Nerve Fibers in the Duodenal Mucosa of Patients With Functional Dyspepsia
- Title
- Degranulated Eosinophils Contain More Fine Nerve Fibers in the Duodenal Mucosa of Patients With Functional Dyspepsia
- Authors
- Lee, Min Jin; Jung, Hye-Kyung; Lee, Ko Eun; Mun, Yeung-Chul; Park, Sanghui
- Ewha Authors
- 정혜경; 문영철; 박상희
- SCOPUS Author ID
- 정혜경; 문영철; 박상희
- Issue Date
- 2019
- Journal Title
- JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY
- ISSN
- 2093-0879
2093-0887
- Citation
- JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY vol. 25, no. 2, pp. 212 - 221
- Keywords
- Duodenum; Dyspepsia; Eosinophils; Inflammation; Peripheral nervous system
- Publisher
- KOREAN SOC NEUROGASTROENTEROLOGY &
MOTILITY
- Indexed
- SCIE; SCOPUS; KCI
- Document Type
- Article
- Abstract
- Background/Aims Functional dyspepsia (FD) is characterized as chronic recurrent upper gastrointestinal symptoms in the absence of any organic disorder. We hypothesized that duodenal low-grade inflammation activates superficial afferent nerve sprouting, thereby contributing to hypersensitivity in patients with FD. Methods A prospective case-control study was conducted in a tertiary referral center. FD was defined using the Rome III criteria. Standardized endoscopic biopsies were performed in the stomach and duodenum. Hematoxylin and eosin staining and immunohistochemical staining for major basic proteins were performed to detect granulated eosinophil-derived granules, and S-100 staining was performed to detect fine nerve fibers. Results A total of 51 patients with FD (82% female; mean age 35.8 +/- 13.4 years) and 35 controls were enrolled. Activated eosinophil counts in the duodenum were significantly higher in patients with FD than in controls (41.4% vs 17.1%, P = 0.005). Microscopic duodenitis was more frequently detected in patients with FD than in controls. Fine nerve fibers were more abundant in patients with FD than in controls (45.1% vs 11.4%, P = 0.029). The abundance of fine nerve fibers highly correlated with the degree of activated eosinophils. Conclusion Duodenal low-grade inflammation, such as mucosal eosinophilic accumulation with degranulation, promoted mucosal enteric nerve fiber density and sprouting in patients with FD.
- DOI
- 10.5056/jnm18176
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
- Files in This Item:
There are no files associated with this item.
- Export
- RIS (EndNote)
- XLS (Excel)
- XML