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dc.contributor.author이승진-
dc.contributor.author김희정-
dc.date.accessioned2019-05-03T16:30:05Z-
dc.date.available2019-05-03T16:30:05Z-
dc.date.issued2019-
dc.identifier.issn0168-3659-
dc.identifier.issn1873-4995-
dc.identifier.otherOAK-24713-
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/249709-
dc.description.abstractDelivery of synovium-resident mesenchymal stem cells (synMSCs) to cartilage defect site might provide a novel therapeutic modally for treatment of articular cartilage diseases. However, low isolation efficiency of synMSCs limits their therapeutic application. Niche-preserving non-enzymatic isolation of synMSCs was firstly attempted by employing micro-organ culture system based on recapitulating tissue-specific homeostasis ex vivo. The isolated synMSCs retained superior long-term growth competency, proliferation and chondrogenic potential to bone marrow-derived MSCs (BMSCs). It was noted that synMSCs demonstrated 9-fold increase in cartilaginous micro-tissue formation and 13-fold increase in sulfated proteoglycans deposition compared to BMSCs. For delivery of synMSCs, fibrous PLGA scaffolds were specifically designed for full-thickness osteochondral defects in rabbits. The scaffolds provided effective micro-environment for growth and host-integration of synMSCs. Combined delivery of synMSCs with bone morphogenetic proteins-7 (BMP-7) was designed to achieve synergistic therapeutic efficacy. BMP-7-loaded PLGA nanoparticles electrosprayed onto the scaffolds released BMP-7 over 2 weeks to conform with its aimed role in stimulating early stage endochondral ossification. Scaffold-supported combined administration of synMSCs with BMP-7 resulted in high proteoglycan and collagen type II induction and thick hyaline cartilage formation. Intra-articular co-delivery of synMSCs with BMP-7 via fibrous PLGA scaffolds may be a promising therapeutic modality for articular cartilage repair.-
dc.languageEnglish-
dc.publisherELSEVIER SCIENCE BV-
dc.subjectSynovium-resident mesenchymal stem cells-
dc.subjectBone morphogenetic protein-7-
dc.subjectCombined delivery-
dc.subjectPLGA fibrous scaffold-
dc.subjectArticular cartilage repair-
dc.titleIntra-articular delivery of synovium-resident mesenchymal stem cells via BMP-7-loaded fibrous PLGA scaffolds for cartilage repair-
dc.typeArticle-
dc.relation.volume302-
dc.relation.indexSCI-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage169-
dc.relation.lastpage180-
dc.relation.journaltitleJOURNAL OF CONTROLLED RELEASE-
dc.identifier.doi10.1016/j.jconrel.2019.04.002-
dc.identifier.wosidWOS:000469421500016-
dc.identifier.scopusid2-s2.0-85064183147-
dc.author.googleKim, Hee Jung-
dc.author.googleHan, Min Ah.-
dc.author.googleShin, Ji Young-
dc.author.googleJeon, Jeong Hwa-
dc.author.googleLee, Seung Jin-
dc.author.googleYoon, Mi Yun-
dc.author.googleKim, Han-Jun-
dc.author.googleChoi, Eun-Ji-
dc.author.googleDo, Sun Hee-
dc.author.googleYang, Victor C.-
dc.author.googleHe, Huining-
dc.author.googleYang, Young-Il-
dc.contributor.scopusid이승진(12545448000)-
dc.contributor.scopusid김희정(14626479600)-
dc.date.modifydate20210727140254-
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약학대학 > 약학과 > Journal papers
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