View : 205 Download: 0

Identification of the TIFAB Gene as a Susceptibility Locus for Coronary Artery Aneurysm in Patients with Kawasaki Disease

Title
Identification of the TIFAB Gene as a Susceptibility Locus for Coronary Artery Aneurysm in Patients with Kawasaki Disease
Authors
Kwon Y.-C.Kim J.-J.Yu J.J.Yun S.W.Yoon K.L.Lee K.-Y.Kil H.-R.Kim G.B.Han M.-K.Song M.S.Lee H.D.Ha K.S.Sohn S.Hong Y.M.Jang G.Y.Lee J.-K.Park I.-S.Hong S.-J.Kim K.-J.Nam H.-K.Byeon J.-H.Rhim J.-W.Kim D.S.Lee J.-M.Kim J.-D.Korean Kawasaki Disease Genetics Consortium
Ewha Authors
홍영미손세정
SCOPUS Author ID
홍영미scopus; 손세정scopus
Issue Date
2019
Journal Title
Pediatric Cardiology
ISSN
0172-0643JCR Link
Citation
Pediatric Cardiology vol. 40, no. 3, pp. 483 - 488
Keywords
Coronary artery aneurysmGenome-wide association studyKawasaki diseaseSingle-nucleotide polymorphismTRAF-interacting protein with FHA domain-containing protein B
Publisher
Springer New York LLC
Indexed
SCI; SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Kawasaki disease (KD) is a self-limiting systemic vasculitis of unknown etiology. KD is often complicated by coronary artery aneurysms (CAAs), which develop in about 20–25% of untreated children and 3–5% of children treated with intravenous immunoglobulin therapy. To identify the risk loci for CAA susceptibility in patients with KD, we performed a genome-wide association study (GWAS) using our previous Illumina HumanOmni1-Quad BeadChip data (296 KD patients) and a new replication study in an independent sample set (713 KD patients) by grouping KD patients without CAA (control) versus KD patients with extremely large aneurysms (diameter ≥ 5 mm) (case). Among 44 candidate single -nucleotide polymorphisms (SNPs) selected from the initial GWAS data (33 cases vs. 215 controls), a SNP (rs899162) located 7 kb upstream of the TIFAB gene on chromosome five was replicated in an independent sample (12 cases vs. 532 controls). In the combined analysis (45 cases vs. 747 controls), the SNP (rs899162) showed a highly significant association with CAA formation (diameter ≥ 5 mm) in patients with KD (odds ratio = 3.20, 95% confidence interval = 2.02–5.05, P combined = 1.95 × 10 −7 ). These results indicate that the TIFAB gene may act as a CAA susceptibility locus in patients with KD. © 2018, Springer Science+Business Media, LLC, part of Springer Nature.
Show the fulltext
DOI
10.1007/s00246-018-1992-7
Appears in Collections:
의과대학 > 의학과 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE