View : 593 Download: 0
Esterification of Secondary Alcohols and Multi-hydroxyl Compounds by Candida antarctica Lipase B and Subtilisin
- Title
- Esterification of Secondary Alcohols and Multi-hydroxyl Compounds by Candida antarctica Lipase B and Subtilisin
- Authors
- Cha, Hee-Jeong; Park, Jin-Byung; Park, Seongsoon
- Ewha Authors
- 박진병
- SCOPUS Author ID
- 박진병
- Issue Date
- 2019
- Journal Title
- BIOTECHNOLOGY AND BIOPROCESS ENGINEERING
- ISSN
- 1226-8372
1976-3816
- Citation
- BIOTECHNOLOGY AND BIOPROCESS ENGINEERING vol. 24, no. 1, pp. 41 - 47
- Keywords
- secondary alcohols; esterification; CAL-B; subtilisin; esters
- Publisher
- KOREAN SOC BIOTECHNOLOGY &
BIOENGINEERING
- Indexed
- SCIE; SCOPUS; KCI
- Document Type
- Review
- Abstract
- Enzyme-catalyzed esterification of secondary alcohols and multi-hydroxyl compounds is one of the most valuable reactions in organic synthesis. However, it is often difficult to achieve high reaction rates and high regio-selectivities with commonly used enzymes such as lipases and proteases. One of the reasons may include bulky substituents of the secondary alcohols and multi-hydroxyl compounds (e.g., carbohydrates and flavonoids). The stereospecificity pocket of lipases, which is considered as a pocket for the binding of medium substituent, might not accept a large substituent due to steric hindrance. Thereby, this review has focused on the discussion about literature survey and structural feature of the most commonly used lipase (i.e., Candida antarctica lipase B (CAL-B)) and serine-protease (i.e., subtilisin) for acylation of secondary alcohols and complex molecules.
- DOI
- 10.1007/s12257-018-0379-1
- Appears in Collections:
- 공과대학 > 식품생명공학과 > Journal papers
- Files in This Item:
There are no files associated with this item.
- Export
- RIS (EndNote)
- XLS (Excel)
- XML