Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 정송미 | * |
dc.date.accessioned | 2019-04-16T16:30:10Z | - |
dc.date.available | 2019-04-16T16:30:10Z | - |
dc.date.issued | 2019 | * |
dc.identifier.issn | 1533-0028 | * |
dc.identifier.issn | 1938-0674 | * |
dc.identifier.other | OAK-24601 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/249624 | - |
dc.description.abstract | Patients with rectal cancer patients with ypT4N0 (stage II) showed worse recurrence-free survival than those with ypT1-2N1 (stage III). Patients staging ypT4N0 (stage II) had significantly higher locoregional recurrence and distant metastasis rates than those staging ypT1-2N1 (stage III). ypT4N0 (stages II) should be classified to a higher stage in the rectal cancer staging system. Background: In the Surveillance, Epidemiology, and End Results population-based data, the survival curves reversed between T4N0 (stages IIB or IIC) and T1-2N1 (stage IIIA) in rectal cancer. However, T4N0 had a higher stage than T1-2N1 in the current colorectal staging system. Patients and Methods: We analyzed 1804 patients with rectal cancer who were treated with preoperative chemoradiotherapy and curative surgery. We grouped patients by pathologic stage, and recurrence-free survival (RFS) and overall survival rates were calculated and compared for each stage. We evaluated prognostic factors that influenced recurrence and survival. Results: In the recurrence and survival analysis, 3-year RFS rates were 95.9% for ypStage 0, 94.0% for ypStage I, 78.9% for ypStage IIA, 55.8% for ypStage IIB/C, 80.2% for ypStage IIIA, 64.6% for ypStage IIIB, and 44.9% for ypStage IIIC. Patients with ypStage IIB/C showed significantly worse RFS (P = .004) than did those with ypStage IIIA. The ypStage IIB/C group showed significantly higher rates of both locoregional recurrence (24.3% vs. 5.5%; P = .02) and distant metastasis (31.6% vs. 17.1%; P = .048) than did the ypStage IIIA group. Compared with ypStage IIIA, ypStage IIB/C showed significantly higher pre-chemoradiotherapy carcinoembryonic antigen (P = .004), circumferential radial margin involvement (P = .001), and positive perineural invasion (P = .014). Conclusion: Patients with rectal cancer staged ypT4N0 were associated with higher locoregional recurrence and distant metastasis rates than those staged ypT1-2N1 in the current staging system. (C) 2018 Elsevier Inc. All rights reserved. | * |
dc.language | English | * |
dc.publisher | CIG MEDIA GROUP, LP | * |
dc.subject | Chemoradiation | * |
dc.subject | Pathologic stage | * |
dc.subject | Prognosis | * |
dc.subject | Rectal cancer | * |
dc.subject | Survival | * |
dc.title | Pathologic Staging Inconsistency Between ypT4N0 (stage II) and ypT1-2N1 (stage III) After Preoperative Chemoradiotherapy and Total Mesorectal Excision in Rectal Cancer: A Multi-Institutional Study | * |
dc.type | Article | * |
dc.relation.issue | 1 | * |
dc.relation.volume | 18 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | E130 | * |
dc.relation.lastpage | E139 | * |
dc.relation.journaltitle | CLINICAL COLORECTAL CANCER | * |
dc.identifier.doi | 10.1016/j.dcc.2018.11.003 | * |
dc.identifier.wosid | WOS:000462041100013 | * |
dc.author.google | Lee, Joo Hwan | * |
dc.author.google | Yu, Mina | * |
dc.author.google | Kim, Sung Hwan | * |
dc.author.google | Lee, Jong Hoon | * |
dc.author.google | Sung, Soo-Yoon | * |
dc.author.google | Jeong, Bae Kwon | * |
dc.author.google | Jeong, Songmi | * |
dc.author.google | Nam, Taek Keun | * |
dc.author.google | Jeong, Jae Uk | * |
dc.author.google | Jang, Hong Seok | * |
dc.contributor.scopusid | 정송미(55756694500) | * |
dc.date.modifydate | 20240318140240 | * |