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Sublingual Immunization With an RSV G Glycoprotein Fragment Primes IL-17-Mediated Immunopathology Upon Respiratory Syncytial Virus Infection

Title
Sublingual Immunization With an RSV G Glycoprotein Fragment Primes IL-17-Mediated Immunopathology Upon Respiratory Syncytial Virus Infection
Authors
Cheon, In SuKim, Joo YoungChoi, YoungjooShim, Byoung-ShikChoi, Jung-ahJung, Dae-ImKim, Jae-OukBraciale, Thomas J.Youn, HyewonSong, Man KiChang, Jun
Ewha Authors
장준김주영
SCOPUS Author ID
장준scopus; 김주영scopusscopus
Issue Date
2019
Journal Title
FRONTIERS IN IMMUNOLOGY
ISSN
1664-3224JCR Link
Citation
FRONTIERS IN IMMUNOLOGY vol. 10
Keywords
RSVglycoproteinsublingualIL-17immunopathology
Publisher
FRONTIERS MEDIA SA
Indexed
SCIE; SCOPUS WOS
Document Type
Article
Abstract
Respiratory syncytial virus (RSV) is the leading cause of serious respiratory tract disease but there is no licensed RSV vaccine. Immunopathological mechanisms have long been suspected as operating in the development of severe RSV disease and have hampered the development of safe and effective vaccines. Here, we show that unlike intranasal immunization, sublingual immunization with RSV glycoprotein fragment containing the central conserved region (Gcf) primes the host for severe disease upon RSV challenge. This increased pathology does not require replication by the challenge virus and is associated with massive infiltration of inflammatory cells, extensive cell death, and excessive mucus production in the airway and lungs. This exacerbated RSV disease primed by sublingual Gcf immunization is distinct from the immunopathology by G-expressing vaccinia virus or formalin-inactivated RSV, and preceded by prominent IL-17 production. IL-17 deficiency abolished the enhanced disease. Our results suggest a novel mechanism of RSV vaccine-induced immunopathology by IL-17, and highlights the importance of vaccination site.
DOI
10.3389/fimmu.2019.00567
Appears in Collections:
약학대학 > 약학과 > Journal papers
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