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Saccharoquinoline, a Cytotoxic Alkaloidal Meroterpenoid from Marine-Derived Bacterium Saccharomonospora sp.
- Saccharoquinoline, a Cytotoxic Alkaloidal Meroterpenoid from Marine-Derived Bacterium Saccharomonospora sp.
- Le, Tu Cam; Lee, Eun Ju; Lee, Jihye; Hong, Ahreum; Yim, Chae-Yoon; Yang, Inho; Choi, Hyukjae; Chin, Jungwook; Cho, Sung Jin; Ko, Jaeyoung; Hwang, Hayoung; Nam, Sang-Jip; Fenical, William
- Ewha Authors
- SCOPUS Author ID
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- Journal Title
- MARINE DRUGS
- MARINE DRUGS vol. 17, no. 2
- Saccharomonospora sp; meroterpenoid; marine natural product; cytotoxicity
- SCIE; SCOPUS
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- A cytotoxic alkaloidal meroterpenoid, saccharoquinoline (1), has been isolated from the fermentation broth of the marine-derived bacterium Saccharomonospora sp. CNQ-490. The planar structure of 1 was elucidated by 1D, 2D NMR, and MS spectroscopic data analyzes, while the relative configuration of 1 was defined through the interpretation of NOE spectroscopic data. Saccharoquinoline (1) is composed of a drimane-type sesquiterpene unit in combination with an apparent 6,7,8-trihydroxyquinoline-2-carboxylic acid. This combination of biosynthetic pathways was observed for the first time in natural microbial products. Saccharoquinoline (1) was found to have cytotoxicity against the HCT-116 cancer cell line by inducing G1 arrest, which leads to cell growth inhibition.
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