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Saccharoquinoline, a Cytotoxic Alkaloidal Meroterpenoid from Marine-Derived Bacterium Saccharomonospora sp.
- Title
- Saccharoquinoline, a Cytotoxic Alkaloidal Meroterpenoid from Marine-Derived Bacterium Saccharomonospora sp.
- Authors
- Le, Tu Cam; Lee, Eun Ju; Lee, Jihye; Hong, Ahreum; Yim, Chae-Yoon; Yang, Inho; Choi, Hyukjae; Chin, Jungwook; Cho, Sung Jin; Ko, Jaeyoung; Hwang, Hayoung; Nam, Sang-Jip; Fenical, William
- Ewha Authors
- 남상집
- SCOPUS Author ID
- 남상집
- Issue Date
- 2019
- Journal Title
- MARINE DRUGS
- ISSN
- 1660-3397
- Citation
- MARINE DRUGS vol. 17, no. 2
- Keywords
- Saccharomonospora sp; meroterpenoid; marine natural product; cytotoxicity
- Publisher
- MDPI
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- A cytotoxic alkaloidal meroterpenoid, saccharoquinoline (1), has been isolated from the fermentation broth of the marine-derived bacterium Saccharomonospora sp. CNQ-490. The planar structure of 1 was elucidated by 1D, 2D NMR, and MS spectroscopic data analyzes, while the relative configuration of 1 was defined through the interpretation of NOE spectroscopic data. Saccharoquinoline (1) is composed of a drimane-type sesquiterpene unit in combination with an apparent 6,7,8-trihydroxyquinoline-2-carboxylic acid. This combination of biosynthetic pathways was observed for the first time in natural microbial products. Saccharoquinoline (1) was found to have cytotoxicity against the HCT-116 cancer cell line by inducing G1 arrest, which leads to cell growth inhibition.
- DOI
- 10.3390/md17020098
- Appears in Collections:
- 자연과학대학 > 화학·나노과학전공 > Journal papers
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