Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 권오란 | * |
dc.date.accessioned | 2019-03-27T16:30:05Z | - |
dc.date.available | 2019-03-27T16:30:05Z | - |
dc.date.issued | 2019 | * |
dc.identifier.issn | 2045-2322 | * |
dc.identifier.other | OAK-24511 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/249507 | - |
dc.description.abstract | It is unclear whether dietary lutein/zeaxanthin intake in colorectal cancer is associated with microRNA processing involved in DICER1 cleavage for messenger RNA translation. We investigated whether dietary lutein/zeaxanthin intake affects colorectal cancer risk in patients with a DICER1 rs3742330 polymorphism. In this hospital-based case-control study, we recruited 923 colorectal cancer patients and 1,846 controls based on eligibility criteria, a semiquantitative food frequency questionnaire and the DICER1 rs3742330 genotype. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by unconditional logistic regression adjusted for confounders. The highest quartile of lutein/zeaxanthin consumption was inversely associated with a reduced colorectal cancer risk (OR, 95% CI = 0.25, 0.18–0.36). Carrying G allele (AG + GG) showed a significantly reduced colorectal cancer incidence compared with that of AA carriers (OR, 95% CI = 0.71, 0.55–0.91). Those carrying the G allele (AG + GG) along with high lutein/zeaxanthin consumption were markedly associated with a decreased colorectal cancer risk (OR, 95% CI = 0.32, 0.22–0.46, P for interaction = 0.018), particularly for rectal cancer (OR, 95% CI = 0.24, 0.15–0.39, P for interaction = 0.004), compared with that of AA carriers with low lutein/zeaxanthin intakes. In conclusion, colorectal cancer risk was related to an interactive effect between dietary lutein/zeaxanthin intake and the DICER1 rs3742330 polymorphism. © 2019, The Author(s). | * |
dc.language | English | * |
dc.publisher | Nature Publishing Group | * |
dc.title | Dietary Lutein Plus Zeaxanthin Intake and DICER1 rs3742330 A > G Polymorphism Relative to Colorectal Cancer Risk | * |
dc.type | Article | * |
dc.relation.issue | 1 | * |
dc.relation.volume | 9 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | Scientific Reports | * |
dc.identifier.doi | 10.1038/s41598-019-39747-5 | * |
dc.identifier.wosid | WOS:000460123600078 | * |
dc.identifier.scopusid | 2-s2.0-85062382626 | * |
dc.author.google | Kim J. | * |
dc.author.google | Lee J. | * |
dc.author.google | Oh J.H. | * |
dc.author.google | Chang H.J. | * |
dc.author.google | Sohn D.K. | * |
dc.author.google | Kwon O. | * |
dc.author.google | Shin A. | * |
dc.contributor.scopusid | 권오란(55713470100) | * |
dc.date.modifydate | 20240123125010 | * |