Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이공주 | * |
dc.contributor.author | 하헌주 | * |
dc.date.accessioned | 2019-02-26T16:30:04Z | - |
dc.date.available | 2019-02-26T16:30:04Z | - |
dc.date.issued | 2019 | * |
dc.identifier.issn | 2045-2322 | * |
dc.identifier.other | OAK-24416 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/249383 | - |
dc.description.abstract | Long-term peritoneal dialysis is associated with progressive fibrosis of the peritoneum. Epithelial-mesenchymal transition (EMT) of mesothelial cells is an important mechanism involved in peritoneal fibrosis, and TGF-β1 is considered central in this process. However, targeting currently known TGF-β1-associated pathways has not proven effective to date. Therefore, there are still gaps in understanding the mechanisms underlying TGF-β1-associated EMT and peritoneal fibrosis. We conducted network-based integrated analysis of transcriptomic and proteomic data to systemically characterize the molecular signature of TGF-β1-stimulated human peritoneal mesothelial cells (HPMCs). To increase the power of the data, multiple expression datasets of TGF-β1-stimulated human cells were employed, and extended based on a human functional gene network. Dense network sub-modules enriched with differentially expressed genes by TGF-β1 stimulation were prioritized and genes of interest were selected for functional analysis in HPMCs. Through integrated analysis, ECM constituents and oxidative stress-related genes were shown to be the top-ranked genes as expected. Among top-ranked sub-modules, TNFAIP6, ZC3H12A, and NNT were validated in HPMCs to be involved in regulation of E-cadherin, ZO-1, fibronectin, and αSMA expression. The present data shows the validity of network-based integrated analysis in discovery of novel players in TGF-β1-induced EMT in peritoneal mesothelial cells, which may serve as new prognostic markers and therapeutic targets for peritoneal dialysis patients. © 2019, The Author(s). | * |
dc.language | English | * |
dc.publisher | Nature Publishing Group | * |
dc.title | Network-based integrated analysis of omics data reveal novel players of TGF-β1-induced EMT in human peritoneal mesothelial cells | * |
dc.type | Article | * |
dc.relation.issue | 1 | * |
dc.relation.volume | 9 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | Scientific Reports | * |
dc.identifier.doi | 10.1038/s41598-018-37101-9 | * |
dc.identifier.wosid | WOS:000457868400043 | * |
dc.identifier.scopusid | 2-s2.0-85061128664 | * |
dc.author.google | Han S.M. | * |
dc.author.google | Ryu H.-M. | * |
dc.author.google | Suh J. | * |
dc.author.google | Lee K.-J. | * |
dc.author.google | Choi S.-Y. | * |
dc.author.google | Choi S. | * |
dc.author.google | Kim Y.-L. | * |
dc.author.google | Huh J.Y. | * |
dc.author.google | Ha H. | * |
dc.contributor.scopusid | 이공주(7501497635;57191532162) | * |
dc.contributor.scopusid | 하헌주(7202277106) | * |
dc.date.modifydate | 20240422113229 | * |