View : 261 Download: 0
Alterations in structural rich-club connectivity of the precuneus are associated with depressive symptoms among individuals with subjective memory complaints
- Alterations in structural rich-club connectivity of the precuneus are associated with depressive symptoms among individuals with subjective memory complaints
- Kim G.H.; Kim J.Y.; Kim J.E.; Ma J.; Kim B.R.; Im J.J.; Jeong H.S.; Namgung E.; Lee S.; Kang I.; Lyoo I.K.; Hwang J.; Yoon S.
- Ewha Authors
- 김지은; 류인균; 윤수정; 김정윤; 김건하
- SCOPUS Author ID
- 김지은; 류인균; 윤수정; 김정윤; 김건하
- Issue Date
- Journal Title
- Cognitive, Affective and Behavioral Neuroscience
- Cognitive, Affective and Behavioral Neuroscience vol. 19, no. 1, pp. 73 - 87
- Depressive symptoms; Network analysis; Precuneus; Rich-club organization; Structural brain network; Subjective memory complaints
- Springer New York LLC
- SCIE; SCOPUS
- Document Type
- The association between subjective memory complaints (SMCs) and depressive symptoms has been widely reported and both have been regarded as risk factors for dementia, such as Alzheimer’s disease (AD). Although SMCs arise as early as in middle age, the exact neural correlates of comorbid depressive symptoms among individuals who are middle-aged and with SMCs have not yet been well investigated. Because rich-club organization of the brain plays a key role in the pathophysiology of various neuropsychiatric disorders, the investigation of rich club organization may provide insight regarding the neurobiological mechanisms of depressive symptoms in SMCs. In the current study, we compared the rich-club organization in the structural brain connectivity between individuals who have SMCs along with depressive symptoms (SMCD) and individuals with SMCs but without depressive symptoms (SMCO). A total of 53 individuals with SMCD and 91 individuals with SMCO participated in the study. For all participants, high-resolution, T1-weighted images and diffusion tensor images were obtained, and the network analysis was performed. Individuals with SMCD had lower connectivity strength between the precuneus and other rich-club nodes than those with SMCO, which was significant after adjusting for potential confounders. Our findings suggest that disruptions of rich-club connectivity strength of the precuenus are associated with depressive symptoms in middle-aged individuals with SMCs. Given that the precuneus is one of the commonly affected regions in the early stages of AD, our findings may imply that the concomitant depressive symptoms in middle-aged individuals with SMCs could reflect structural alterations related to AD. © 2018, Psychonomic Society, Inc.
- Appears in Collections:
- 일반대학원 > 뇌·인지과학과 > Journal papers
- Files in This Item:
There are no files associated with this item.
- RIS (EndNote)
- XLS (Excel)
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.