Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 이상혁 | * |
dc.contributor.author | 김재상 | * |
dc.date.accessioned | 2019-01-28T16:30:08Z | - |
dc.date.available | 2019-01-28T16:30:08Z | - |
dc.date.issued | 2019 | * |
dc.identifier.issn | 1535-6108 | * |
dc.identifier.other | OAK-24255 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/248308 | - |
dc.description.abstract | We report proteogenomic analysis of diffuse gastric cancers (GCs) in young populations. Phosphoproteome data elucidated signaling pathways associated with somatic mutations based on mutation-phosphorylation correlations. Moreover, correlations between mRNA and protein abundances provided potential oncogenes and tumor suppressors associated with patient survival. Furthermore, integrated clustering of mRNA, protein, phosphorylation, and N-glycosylation data identified four subtypes of diffuse GCs. Distinguishing these subtypes was possible by proteomic data. Four subtypes were associated with proliferation, immune response, metabolism, and invasion, respectively; and associations of the subtypes with immune- and invasion-related pathways were identified mainly by phosphorylation and N-glycosylation data. Therefore, our proteogenomic analysis provides additional information beyond genomic analyses, which can improve understanding of cancer biology and patient stratification in diffuse GCs. © 2018 Elsevier Inc.Mun et al. perform proteogenomic analysis of diffuse gastric cancers (DGC) in a young population, identifying that correlations of mRNA-protein abundance associate with survival and defining four subtypes of DGC. The associations of some subtypes with related pathways are identified mainly by the proteomic data. © 2018 Elsevier Inc. | * |
dc.language | English | * |
dc.publisher | Cell Press | * |
dc.subject | cancer subtypes | * |
dc.subject | correlation between mRNA and protein abundance changes | * |
dc.subject | correlation between mutation and phosphorylation | * |
dc.subject | diffuse gastric cancer | * |
dc.subject | proteogenomics | * |
dc.subject | somatic nonsynonymous mutations | * |
dc.title | Proteogenomic Characterization of Human Early-Onset Gastric Cancer | * |
dc.type | Article | * |
dc.relation.issue | 1 | * |
dc.relation.volume | 35 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 111 | * |
dc.relation.lastpage | 1.24E12 | * |
dc.relation.journaltitle | Cancer Cell | * |
dc.identifier.doi | 10.1016/j.ccell.2018.12.003 | * |
dc.identifier.wosid | WOS:000455719400012 | * |
dc.identifier.scopusid | 2-s2.0-85059409840 | * |
dc.author.google | Mun D.-G. | * |
dc.author.google | Bhin J. | * |
dc.author.google | Kim S. | * |
dc.author.google | Kim H. | * |
dc.author.google | Jung J.H. | * |
dc.author.google | Jung Y. | * |
dc.author.google | Jang Y.E. | * |
dc.author.google | Park J.M. | * |
dc.author.google | Lee H. | * |
dc.author.google | Bae J. | * |
dc.author.google | Back S. | * |
dc.author.google | Kim S.-J. | * |
dc.author.google | Kim J. | * |
dc.author.google | Park H. | * |
dc.author.google | Li H. | * |
dc.author.google | Hwang K.-B. | * |
dc.author.google | Park Y.S. | * |
dc.author.google | Yook J.H. | * |
dc.author.google | Kim B.S. | * |
dc.author.google | Kwon S.Y. | * |
dc.author.google | Ryu S.W. | * |
dc.author.google | Park D.Y. | * |
dc.author.google | Jeon T.Y. | * |
dc.author.google | Kim D.H. | * |
dc.author.google | Lee J.-H. | * |
dc.author.google | Han S.-U. | * |
dc.author.google | Song K.S. | * |
dc.author.google | Park D. | * |
dc.author.google | Park J.W. | * |
dc.author.google | Rodriguez H. | * |
dc.author.google | Kim K.P. | * |
dc.author.google | Yang E.G. | * |
dc.author.google | Kim H.K. | * |
dc.author.google | Paek E. | * |
dc.author.google | Lee S. | * |
dc.author.google | Lee S.-W. | * |
dc.author.google | Hwang D. | * |
dc.contributor.scopusid | 이상혁(57212112170) | * |
dc.contributor.scopusid | 김재상(8643335800) | * |
dc.date.modifydate | 20240415122632 | * |