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CHA(2)DS(2)-VASc score predicts exercise intolerance in young and middle-aged male patients with asymptomatic atrial fibrillation
- Title
- CHA(2)DS(2)-VASc score predicts exercise intolerance in young and middle-aged male patients with asymptomatic atrial fibrillation
- Authors
- Yi, Jeong-Eun; Lee, Young Soo; Choi, Eue-Keun; Cha, Myung-Jin; Kim, Tae-Hoon; Park, Jin-Kyu; Lee, Jung-Myung; Kang, Ki-Woon; Shim, Jaemin; Uhm, Jae-Sun; Kim, Jun; Kim, Changsoo; Kim, Jin-Bae; Park, Hyung Wook; Joung, Boyoung; Park, Junbeom
- Ewha Authors
- 박준범; 이정은
- SCOPUS Author ID
- 박준범; 이정은
- Issue Date
- 2018
- Journal Title
- SCIENTIFIC REPORTS
- ISSN
- 2045-2322
- Citation
- SCIENTIFIC REPORTS vol. 8
- Publisher
- NATURE PUBLISHING GROUP
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Exercise intolerance among the clinical symptoms in patients with atrial fibrillation (AF) has usually been masked by their adjusted life style. We sought to assess the role of CHA(2)DS(2)-VASc score to predict exercise intolerance in asymptomatic AF patients, and further examine whether the relationship differs by age and gender. Among the 6,275 participants of the prospective Korean registry of the Comparison study of Drugs for symptom control and complication prevention of Atrial Fibrillation (CODE-AF), 1,080 AF patients who underwent exercise treadmill testing were studied. Exercise intolerance was defined as a peak exercise capacity of 7 metabolic equivalents (METs) or less, and the patients were divided into two groups for the analysis: <= 7 METs (n = 131) and >7 METs (n = 949). Patients with exercise intolerance had a significantly higher CHA(2)DS(2)-VASc score than those without (3.1 +/- 1.3 vs. 2.0 +/- 1.5, p < 0.0001). In the multivariate analysis, a higher CHA(2)DS(2)-VASc score (OR 1.54, 95% CI 1.31-1.81, p < 0.0001), corrected QT interval (OR 1.01, 95% CI 1.00-1.02, p = 0.026), and increased left atrial volume index (OR 1.02, 95% CI 1.01-1.03, p = 0.001) were found to be independent predictors of exercise intolerance. The impact of the CHA(2)DS(2)-VASc score on exercise intolerance was significant only in male patients aged < 65 years (OR 3.30, 95% CI 1.76-6.19, p < 0.0001). The CHA(2)DS(2)-VASc score may be a feasible risk assessment tool to predict exercise intolerance, especially in young and middle-aged male patients with asymptomatic AF.
- DOI
- 10.1038/s41598-018-36185-7
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
- Files in This Item:
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CHA2DS2-VASc score.pdf(1.28 MB)
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