Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 이지수 | - |
dc.date.accessioned | 2019-01-24T16:30:11Z | - |
dc.date.available | 2019-01-24T16:30:11Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.other | OAK-24144 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/248239 | - |
dc.description.abstract | Background: To evaluate the therapeutic benefits of the treat-to-target (T2T) strategy for Asian patients with early rheumatoid arthritis (RA) in Korea. Methods: In a 1-year, multicenter, open-label strategy trial, 346 patients with early RA were recruited from 20 institutions across Korea and stratified into 2 groups, depending on whether they were recruited by rheumatologists who have adopted the T2T strategy (T2T group) or by rheumatologists who provided usual care (non-T2T group). Data regarding demographics, rheumatoid factor titer, anti-cyclic citrullinated peptide antibody titer, disease activity score of 28 joints (DAS28), and Korean Health Assessment Questionnaire (KHAQ) score were obtained at baseline and after 1 year of treatment. In the T2T group, the prescription for disease-modifying antirheumatic drugs was tailored to the predefined treatment target in each patient, namely remission (DAS28 < 2.6) or low disease activity (LDA) (2.6 ≤ DAS28 < 3.2). Results: Data were available for 163 T2T patients and 162 non-T2T patients. At the end of the study period, clinical outcomes were better in the T2T group than in the non-T2T group (LDA or remission, 59.5% vs. 35.8%; P < 0.001; remission, 43.6% vs. 19.8%; P < 0.001). Compared with non-T2T, T2T was also associated with higher rate of good European League Against Rheumatism response (63.0% vs. 39.8%; P < 0.001), improved KHAQ scores (-0.38 vs. -0.13; P = 0.008), and higher frequency of follow-up visits (5.0 vs. 2.0 visits/year; P < 0.001). Conclusion: In Asian patients with early RA, T2T improves disease activity and physical function. Setting a pre-defined treatment target in terms of DAS28 is recommended. © 2018 The Korean Academy of Medical Sciences. | - |
dc.language | English | - |
dc.publisher | Korean Academy of Medical Science | - |
dc.subject | Rheumatoid arthritis | - |
dc.subject | Treat-to-target | - |
dc.subject | Treatment outcome | - |
dc.title | Treat-to-target strategy for asian patients with early rheumatoid arthritis: Result of a multicenter trial in Korea | - |
dc.type | Article | - |
dc.relation.issue | 52 | - |
dc.relation.volume | 33 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.index | KCI | - |
dc.relation.journaltitle | Journal of Korean Medical Science | - |
dc.identifier.doi | 10.3346/jkms.2018.33.e346 | - |
dc.identifier.wosid | WOS:000454243800007 | - |
dc.identifier.scopusid | 2-s2.0-85058910437 | - |
dc.author.google | Song J.J. | - |
dc.author.google | Song Y.W. | - |
dc.author.google | Bae S.C. | - |
dc.author.google | Cha H.-S. | - |
dc.author.google | Choe J.-Y. | - |
dc.author.google | Choi S.J. | - |
dc.author.google | Kim H.A. | - |
dc.author.google | Kim J. | - |
dc.author.google | Kim S.-S. | - |
dc.author.google | Lee C.-K. | - |
dc.author.google | Lee J. | - |
dc.author.google | Lee S.-H. | - |
dc.author.google | Lee S.-S. | - |
dc.author.google | Lee S.-K. | - |
dc.author.google | Lee S.W. | - |
dc.author.google | Park S.-H. | - |
dc.author.google | Park W. | - |
dc.author.google | Shim S.C. | - |
dc.author.google | Suh C.-H. | - |
dc.author.google | Yoo B. | - |
dc.author.google | Yoo D.-H. | - |
dc.author.google | Yoo W.-H. | - |
dc.contributor.scopusid | 이지수(14424388700) | - |
dc.date.modifydate | 20230201112642 | - |