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Scalalactams A–D, scalarane sesterterpenes with a γ-lactam moiety from a Korean Spongia sp. Marine sponge

Title
Scalalactams A–D, scalarane sesterterpenes with a γ-lactam moiety from a Korean Spongia sp. Marine sponge
Authors
Yang I.Lee J.Hahn D.Chin J.Won D.H.Ko J.Choi H.Hong A.Nam S.-J.Kang H.
Ewha Authors
남상집
SCOPUS Author ID
남상집scopusscopus
Issue Date
2018
Journal Title
Molecules
ISSN
1420-3049JCR Link
Citation
Molecules vol. 23, no. 12
Keywords
Marine natural productsMarine spongeScalalactamsScalarane sesterterpenesSpongia sp
Publisher
MDPI AG
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Intensive study on the chemical components of a Korean marine sponge, Spongia sp., has led to the isolation of four new scalarane sesterterpenes, scalalactams A–D (1–4). Their chemical structures were elucidated from the analysis of spectroscopic data including 1D-and 2D-NMR as well as MS data. Scalalactams A–D (1–4) possess a scalarane carbon skeleton with a rare structural feature of a γ-lactam moiety within the molecules. Scalalactams A and B (1 and 2) have an extended isopropanyl chain at the lactam ring, and scalalactams C and D (3 and 4) possess a phenethyl group at the lactam ring moiety. Scalalactams A–D (1–4) did not show FXR antagonistic activity nor cytotoxicity up to 100 μM. © 2018 by the authors.
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DOI
10.3390/molecules23123187
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
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