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Perinatal Exposure to Arsenic in Drinking Water Alters Glutamatergic Neurotransmission in the Striatum of C57BL/6 Mice
- Title
- Perinatal Exposure to Arsenic in Drinking Water Alters Glutamatergic Neurotransmission in the Striatum of C57BL/6 Mice
- Authors
- Sung, Kyunghwa; Kim, Minjeong; Kim, Haesoo; Hwang, Gi-Wook; Kim, Kisok
- Ewha Authors
- 김민정
- SCOPUS Author ID
- 김민정
- Issue Date
- 2019
- Journal Title
- BIOLOGICAL TRACE ELEMENT RESEARCH
- ISSN
- 0163-4984
1559-0720
- Citation
- BIOLOGICAL TRACE ELEMENT RESEARCH vol. 187, no. 1, pp. 224 - 229
- Keywords
- Arsenic; Glutamate; mGluR2; mGluR3; Striatum; VGLUT2
- Publisher
- HUMANA PRESS INC
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Although exposure to arsenic (As) induces developmental neurotoxicity, there is a lack of data regarding its specific effects on glutamatergic neurotransmission in offspring from dams exposed to As during gestation and lactation. In this study, the body weight, glutamate content, and expression of vesicular glutamate transporter 2 (VGLUT2) and metabotropic glutamate receptors mGluR2 and mGluR3 was examined in the striatum of offspring following treatment of the dams with As (10 or 100mg/L NaAsO2 in drinking water). At postnatal day 21, body weight was decreased significantly, whereas the glutamate content in the striatum of offspring in the 100-mg/L As group were not significantly different from those in the control group. Although mGluR3 expression was not significantly different, VGLUT2 and mGluR2 expression was significantly lower in the striatum of offspring of As-exposed dams. These data indicate that altered glutamatergic neurotransmission may contribute to As-induced developmental neurotoxic effects.
- DOI
- 10.1007/s12011-018-1374-2
- Appears in Collections:
- 연구기관 > 약학연구소 > Journal papers
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